| Notch信号通路与Slug在调控宫颈鳞状细胞癌上皮-间充质转变中的意义 |
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| 引用本文： | 王晓萌,丁洋,王晓梅,王恩杰,高峰.Notch信号通路与Slug在调控宫颈鳞状细胞癌上皮-间充质转变中的意义[J].解剖科学进展,2012,18(6):522-525. |
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| 作者姓名： | 王晓萌 丁洋 王晓梅 王恩杰 高峰 |
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| 作者单位： | 1. 河北医科大学第三医院病理科,石家庄,050051
2. 邢台市第三医院病理科,邢台,054000 |
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| 基金项目： | 河北省医学科学研究重点课题计划 |
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| 摘 要： | 目的探讨Notch信号通路与Slug在宫颈鳞状细胞癌上皮-间充质转变(EMT)中的作用机制。方法收集临床慢性宫颈炎及宫颈鳞状细胞癌标本,分别用免疫组化及Western blot检测Notch1、NICD1、Slug、E-cadherin、α-SMA蛋白表达情况,Real-Time PCR检测Notch1、SlugmRNA表达情况。结果与慢性宫颈炎比较,Notch1、NICD1、Slug和α-SMA在宫颈鳞状细胞癌中表达增加(P<0.01),E-cadherin蛋白在癌组织中的表达降(P<0.01)。结论 Notch信号通路和Slug可能通过调控EMT在宫颈鳞状细胞癌的侵袭转移过程中发挥作用
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| 关 键 词： | Notch Slug 宫颈 鳞状细胞癌 上皮-间充质转变 |
Notch pathway and Slug regulate epithelial-mesenchymal transition of squamous cell carcinoma in cervix |
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| WANG Xiao-meng
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DING Yang
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WANG Xiao-mei
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WANG En-jie
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GAO Feng.Notch pathway and Slug regulate epithelial-mesenchymal transition of squamous cell carcinoma in cervix[J].Progress of Anatomical Sciences,2012,18(6):522-525. |
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| Authors: | WANG Xiao-meng DING Yang WANG Xiao-mei WANG En-jie GAO Feng |
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| Institution: | 1.Department of Pathology,Third Hospital of Hebei Medical University,Shijiazhuang050051;2.Department of Pathology, Third Hospital of Xingtai, Xingtai 054000, China) |
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| Abstract: | Objective To investigate the effect and mechanism that Notch pathway and Slug regulate epithelial-mesenchymal transition(EMT) of squamous cell carcinoma in cervix. Methods The proteins and mRNA levels of Notch1, NICD1, Slug, E-cadherin and α-SMA were determinated in chronic cervicitis and squamous cell carcinoma specimens by immunohistochemistry, Western blot and real-time PCR. Results The levels of Notch1, NICD1, Slug and α -SMA proteins and Notch1mRNA and Slug mRNA in squamous cell carcinoma were higher than those of chronic cervicitis tissues( P<0.01). The expression level of E-cadherin protein was decreased in squamous cell carcinoma compared with chronic cervicitis tissues( P<0.01). Conclusions Notch pathway and Slug expedite invasion by regulating EMT of squamous cell carcinoma in cervix. |
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| Keywords: | Notch Slug cervix squamous cell carcinoma epithelial-mesenchymal transition |
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