炼钒工人的皮炎调查及其病因

本文主要报告对生产钒化合物工人进行皮炎调查的结果。炼钒厂87名接触钒工人皮炎总的患病串为27.6%,各工种患病串范围在20—80%,提示皮炎的发生与接触浓度有一定关系,而对照组28人无皮炎发生。钒酸钠斑贴试验接触组发生和未发生过皮炎的阳性率分别为26%和7%,对照组均为阴性。豚鼠钒酸钠致敏试验结果阳性。皮炎患者外周血淋巴细胞刺激指数为109±57.2,对照93±64。7,P>0.05,致敏豚鼠脾脏淋巴细胞刺激指数(20.3±3.5)明显高于对照(2.2±1.1),P<0.01。结论认为炼钒工人的皮炎与接触钒有关,钒化合物对皮肤的作用可能具有两重性,即原发性刺激作用和致敏作用。

Studies on Dermatitis and Its Etiopathology in Vanadium smelters

87 male smelters in a vanadium smeltery were examined for skindisease,The results were compared with a group of 28 normal persons.Not a single case of dermatitis was found in the control group,whilerate of dermatitis among exposed workers was 27.6%,rangingfrom 20-80% of different type in pioduclion.It was correlated with theconcentration of vanadium exposed to.The positive rate of patch test invanadium workers was 26% and 7% respectively in workers who hadsuffered from dermatitis and in those who had not.All contnols showednegativenesponses.In guinea pigs the sensitization rate with 2% sodiummetavanadate was 60%.The stimulus index of splenic lymphocytes in tre-ated animal was significantly higher than that of the controls.These re-sults indicated that the dermatitis occured in vanadium smelters were re-lated to vanadium exposure.