Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer |
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Authors: | Email author" target="_blank">Yang?Chun-lu?Email author Wang?Yong Zhao?Jun Zhang?Yi-liang |
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Institution: | 1.Department of Thoracic Surgery, The First Affiliated Hospital, China Medical Univercity, Shenyang 110001; 2.Department of Thoracic Surgery, The General Hospital of Benxi Steel Company, Benxi 117000; 3.The Police Hospital of Shenyang City, Shengyang 110003 |
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Abstract: | Objective To study the expressive characteristics of iNOS in non-small cell lung carcinoma (NSCLC) and it’s affection to the prognosis
NSCLC patients.
Methods The expression of iNOS was detected in 50 NSCLC tissues by Immuno-histochemistry technology.
Results There was positive expression in NSCLC (positive rate 38.00%). The expression of iNOS had a correlation with lymph node metastasis
(P<0.05). There was no significant difference between positive expression of iNOS and lung cancer histological types, TNM stages,
T stages (P>0.05). But the data suggested that there was a direct correlation between expression of iNOS and clinical prognosis (P<0.05).
Conclusion Positive expression of iNOS was observed in NSCLC, which correlated with postoperative survival time and lymph node metastasis.
Although iNOS level had no significant relation with T stage, we find the positive rate in T2 stage was much higher than that
in T1 stage. The result suggested that positive expression of iNOS was related to bad clinical prognosis because of promoting
tumor growth and metastasis.
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Keywords: | NSCLC iNOS Prognosis |
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