N-cadherin 、MMP-9 在直肠癌中表达的临床意义

 目的 探讨N-钙黏附素(N-cadherin)、基质金属蛋白酶-9(MMP-9)在直肠癌中表达的临床意义。方法 采用免疫组织化学两步法对80例直肠癌组织中的N-caclherin、MMP-9表达进行检测。结果 (1)N-cadherin在直肠癌组织中的阳性表达率为41．25％，其中A、B期患者和C、D期患者分别为28．9％和57．1％(P<0．05)；淋巴结转移组和无淋巴结转移组分别为58．6％和31．4％(P<0．05)；肝转移组和无肝转移组阳性表达率分别为69．2％。35．8％(P<0．05)。(2)MMP-9在直肠癌组织中的阳性表达率为60％，其中A、B期患者和C、D期患者阳性表达率分别为40％，85．7％(P<0．01)；淋巴结转移组和无淋巴结转移组阳性表达分别为82．8％。47．1％(P<0．01)，发生肝转移组和无肝转移组阳性表达率分别为84．6％，55．2％(P<0．05)。(3)Kaplan-Meier分析，N-cadherin、MMP-9阳性表达者的生存时间和5年生存率明显低于N-cadherin、MMP-9阴性表达者(P<0．01)。结论 Ncadherin、MMP-9的表达与直肠癌关系密切。对判断其预后可能具有重要意义。

Studies on the Clinical Significance of N-cadherin、MMP-9 in Rectal Cancer

Objective 　Studies on the clinical significance of N-cadherin、MMP-9 in Rectal Cancer. Methods The expression of N-cadherin、MMP-9 of 80 cases of rectal cancer were studied with immunohisto-chemical two step stechnique. Results 　( 1 ) The expressive rate of N-cadherin of Rectal Cancer was 41. 25 %. The expression of A-B grade and C-D grade were 28. 9 % and 57. 1 % respectively ( P < 0. 05) . The expression of lymph node metastasis and no lymph node metastasis were 58. 6 % and 31. 4 % respectively ( P < 0. 05) ; The expression of liver metastasis and no liver metastasis were 69. 2 % and 35. 8 % respectively( P < 0. 05) . (2) The expressive rate of MMP-9 of Rectal Cancer was 60 %. The expression of A-B grade and C-D grade were 40 % and 85. 7 % respectively ( P < 0. 01) ; The expression of lymph node metastasis and no lymph node metastasis were 82. 8 % and 47.1%respectively ; The expression of liver metastasis and no liver metastasis were 84. 6 % and 55. 2 % respectively ( P < 0. 05) . (3) The mean survival time and 52year survival rate in cases with positive N2cadherin and MMP-9 expression were significantly shorter than that of cases with negative expression. Conclusion 　The expression of N-cadherin、MMP-9 was closely related to the rectal cancer , and would be a valuable prognostic marker.