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Slow wave sleep and computed tomographic measures of brain morphology in schizophrenia |
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| Authors: | Kathleen L. Benson Edith V. Sullivan Kelvin O. Lim John Lauriello Vincent P. Zarcone Jr. Adolf Pfefferbaum |
| Affiliation: | a Psychiatry Service, 116A, Department of Veterans Affairs Medical Center, 3801 Miranda Avenue, Palo Alto, CA 94304, USA b Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA c Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM 87131-5326, USA |
| Abstract: | To test the hypothesis that slow wave sleep in schizophrenia is inversely correlated with ventricular system volume, polysomnography and computed tomographic (CT) brain imaging were carried out in 14 psychiatric patients who met Research Diagnostic Criteria for schizophrenia (n = 11) or schizoaffective disorder (n = 3). Three measures of ventricular system volume were analyzed: (1) raw ventricular volume expressed in cm3; (2) ventricle-to-brain ratio; and (3) ventricular volume corrected for normal variation in age and head size expressed as a standardized (z) score. All three quantifications of ventricular volume were significantly and inversely correlated with visually scored measures of stage 3 and stage 4 sleep. This finding suggests that the etiology of slow wave sleep deficits in schizophrenia is related either directly or indirectly to underlying brain dysmorphology. |
| Keywords: | Polysomnography Schizoaffective disorder Ventricular system Ventricle-brain ratio |
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