正常眼压性青光眼患者眼部血流的波动性变化

目的：评价正常眼压性青光眼( NTG)患者眼部血流的波动性变化。
　　方法：前瞻性病例对照研究。彩色多普勒超声成像( CDI)用于测量正常眼压性青光眼患者的眼部血流参数-收缩期峰值流速(Vmax),舒张末期血流速度(Vd),最大速度的时间平均值(TAmax),搏动指数(PI),眼动脉(OA)阻力指数(RI)与收缩期/舒张期比值(S/D),视网膜中央动脉( CRA)和睫状后短动脉( SPCA),并对比正常人数值。比较两组采用非配对t检验,P≤0.05时有显著意义。
　　结果：当与正常人组P值分别为0.605,0.254,0.348对比时,正常眼压性青光眼组中眼动脉,视网膜中央动脉和睫状后短动脉的收缩期峰值流速降低。当与正常人组P值分别为0.000,0.014,0.138对比时,正常眼压性青光眼组中三项的舒张末期血流速度降低。当眼动脉P值分别为0.000,0.045,视网膜中央动脉P值为0.000和0.006,睫状后短动脉P值0.024和0.024时,搏动指数和阻力指数增加。当正常人组眼动脉,视网膜中央动脉和睫状后短动脉P值分别为0.047,0.041和0.189时,正常眼压性青光眼组收缩期/舒张期比值增加。
　　结论：研究得出彩色多普勒超声成像是测量青光眼血管组成部分的有效途径。比较正常眼压性青光眼组和正常人组时发现眼部血管血流速度下降,血管阻力指数增加。

Changes in pulsatile ocular blood flow in normal tension glaucoma patients

AIM:To evaluate changes in pulsatile ocular blood flow in normal tension glaucoma ( NTG) patients.
METHODS: In this prospective case control study color Doppler imaging ( CDI ) was used to determine ocular blood flow parameters- peak systolic velocity( Vmax ) , end diastolic velocity ( Vd ) , time average mean of maximum velocity ( TAmax ) , pulsatility index ( PI ) , resistive index ( RI ) and systolic/diastolic ratio ( S/D ) in ophthalmic artery ( OA ) , central retinal artery ( CRA ) and short posterior ciliary artery ( SPCA ) in NTG patients and a comparision was made with the normal subjects. Unpaired Student's t-test was used to compare the two groups and P≤0. 05 was considered significant.
RESULTS:Vmax in OA, CRA and SPCA in the NTG group was decreased when compared to normals with P values 0. 605, 0. 254 and 0. 348 respectively. Vd in the NTG group was also decreased in all the three vessels when compared to the normal subjects with P values 0. 000, 0.014 and 0. 138 in OA, CRA, and SPCA respectively. The PI and RI were increased in all the vessels in the NTG group with P values 0. 000 and 0. 045 for the OA, 0. 000 and 0. 006 for the CRA and 0. 002 and 0. 024 for the SPCA. S/D ratio was increased in the NTG group as compared to normals with P values 0. 047, 0. 041 and 0. 189 in OA, CRA and SPCA respectively.
CONCLUSION: This study concludes that CDI may provide an effective way of measuring part of the vascular component of glaucoma. We found decreased blood flow velocity and increased resistive indices in the ocular vasculature in the NTG group as compared to normal subjects.