| 山西产苦参种子生物碱类化学成分分析及其资源化价值探讨 |
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| 引用本文： | 翁泽斌,段金廒,郭盛,朱振华,顾俊菲,雷振宏,李安平.山西产苦参种子生物碱类化学成分分析及其资源化价值探讨[J].中国中药杂志,2016,41(17):3265-3271. |
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| 作者姓名： | 翁泽斌 段金廒 郭盛 朱振华 顾俊菲 雷振宏 李安平 |
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| 作者单位： | 南京中医药大学 江苏省中药资源产业化过程协同创新中心 国家中医药管理局 中药资源循环利用重点研究室 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心 国家中医药管理局 中药资源循环利用重点研究室 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心 国家中医药管理局 中药资源循环利用重点研究室 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心 国家中医药管理局 中药资源循环利用重点研究室 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023,南京中医药大学 江苏省中药资源产业化过程协同创新中心 国家中医药管理局 中药资源循环利用重点研究室 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023,山西振东道地药材开发有限公司, 山西 长治 046000,山西振东健康产业集团有限公司, 山西 长治 046000 |
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| 基金项目： | 江苏高校中药资源产业化过程协同创新中心建设专项；江苏省“333高层次人才工程”第一层次培养对象项目（2013）；江苏省高校中药学优势学科Ⅱ期建设项目（2014-ysxk） |
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| 摘 要： | 该文基于中药资源化学及中药资源循环利用的研究思路及开发策略,以苦参种子资源化利用为目的,采用UPLC-QTOF-MS和UPLC-TQ-MS联用技术分析了苦参成熟干燥种子中生物碱类资源性化学成分的组成及其含量,并与同属近缘植物苦豆子成熟干燥种子进行比较,以期发现苦参种子的潜在资源利用价值。研究结果显示:苦参种子与苦豆子种子所含生物碱类化学成分组成具有高度相似性;苦参及苦豆子种子中7种生物碱总量分别为11.203,15.506 mg·g-1。其中,氧化苦参碱、氧化槐果碱、槐定碱在苦参种子中的含量较为丰富,提示苦参种子可作为获取苦参碱类生物碱的重要原料资源加以开发利用。研究结果为苦参种子的资源化利用及产业化开发提供了理论基础,为创新苦参资源价值,提升苦参资源的利用效率提供了支撑。
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| 关 键 词： | 苦参 苦豆子 种子 生物碱类 资源化利用 |
| 收稿时间： | 2016/6/11 0:00:00 |
Evaluation analysis of alkaloids in seed of Sophora flavescens from Shanxi province and exploration of its utilization value |
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| WENG Ze-bin,DUAN Jin-ao,GUO Sheng,ZHU Zhen-hu,GU Jun-fei,LEI Zhen-hong and LI An-ping.Evaluation analysis of alkaloids in seed of Sophora flavescens from Shanxi province and exploration of its utilization value[J].China Journal of Chinese Materia Medica,2016,41(17):3265-3271. |
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| Authors: | WENG Ze-bin DUAN Jin-ao GUO Sheng ZHU Zhen-hu GU Jun-fei LEI Zhen-hong and LI An-ping |
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| Institution: | Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, State Administration of Traditional Chinese Medicine Key Laboratory of Chinese Medicinal Resources Recycling Utilization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and FormulaeInnovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, State Administration of Traditional Chinese Medicine Key Laboratory of Chinese Medicinal Resources Recycling Utilization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and FormulaeInnovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, State Administration of Traditional Chinese Medicine Key Laboratory of Chinese Medicinal Resources Recycling Utilization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and FormulaeInnovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, State Administration of Traditional Chinese Medicine Key Laboratory of Chinese Medicinal Resources Recycling Utilization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and FormulaeInnovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, State Administration of Traditional Chinese Medicine Key Laboratory of Chinese Medicinal Resources Recycling Utilization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and FormulaeInnovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China,Shanxi Zhendong Industry Group of Genuine Herbexploitation Co., Ltd., Changzhi 046000, China and Shanxi Zhendong Health Industry Group Co., Ltd., Changzhi 046000, China |
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| Abstract: | According to the research strategy of resource chemistry of Chinese medicinal materials and Chinese medicinal resources recycling utilization, this study intends to explore the potential resource-oriented utilization value of the seed of Sophora flavescens by contrasting with its kindred plant S. alopecuroides. This study established a rapid UPLC-Q-TOF-MS/MS and UPLC-TQ-MS/MS method to determine the alkaloids in the seed of S. flavescens. Results of UPLC-Q-TOF-MS/MS analysis showed that the alkaloids in the seed of S. flavescens were highly similar with S. alopecuroides.In the determination of 7 kinds of alkaloids, the total content was 11.203 and 15.506 mg·g-1 in the seed of S. flavescens and S. alopecuroides, respectively. The content of oxymatrine, oxysophocarpine and sophoridine is high in the seed of S. flavescens. The results indicated that the seeds of S. flavescens. could be an important material resource to obtain alkaloids. |
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| Keywords: | Sophora flavescens Sophora alopecuroides seed alkaloids resources utilization |
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