| 淫羊藿总黄酮仿生酶解肠溶胶囊的制备及评价 |
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| 引用本文： | 刘聪燕,高霞,黄萌萌,彭静,陈彦. 淫羊藿总黄酮仿生酶解肠溶胶囊的制备及评价[J]. 中草药, 2016, 47(20): 3610-3617 |
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| 作者姓名： | 刘聪燕 高霞 黄萌萌 彭静 陈彦 |
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| 作者单位： | 南京中医药大学附属中西医结合医院, 江苏 南京 210028;江苏省中医药研究院 中药组分与微生态研究中心, 江苏 南京 210028;南京中医药大学附属中西医结合医院, 江苏 南京 210028;江苏省中医药研究院 中药组分与微生态研究中心, 江苏 南京 210028;南京中医药大学附属中西医结合医院, 江苏 南京 210028;江苏省中医药研究院 中药组分与微生态研究中心, 江苏 南京 210028;南京中医药大学附属中西医结合医院, 江苏 南京 210028;江苏省中医药研究院 中药组分与微生态研究中心, 江苏 南京 210028;南京中医药大学附属中西医结合医院, 江苏 南京 210028;江苏省中医药研究院 中药组分与微生态研究中心, 江苏 南京 210028 |
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| 基金项目： | 国家自然科学基金资助项目（81173557） |
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| 摘 要： | 目的以淫羊藿总黄酮为模型药物,蜗牛酶为水解酶,加入制剂辅料制备可实时酶解、实时吸收的淫羊藿总黄酮仿生酶解肠溶胶囊,对其处方工艺进行优化和评价。方法以淫羊藿总黄酮释放度为评价指标,采用UV法和单因素实验筛选制备淫羊藿总黄酮仿生酶解肠溶胶囊所需的填充剂种类、用量,崩解剂种类、用量及润湿剂种类等关键因素,并采用响应面法优化其制剂处方,同时采用HPLC法对肠溶胶囊中4种主要黄酮苷(淫羊藿苷及朝藿定A、B、C)的酶解过程进行考察。结果淫羊藿总黄酮仿生酶解肠溶胶囊的最优处方为淫羊藿总黄酮提取物100 mg,蜗牛酶68 mg,α-乳糖65 mg,低取代羟丙纤维素11.7 mg,该制剂在人工肠液中45 min内的总黄酮累积释放率可达85.43%,同时能够在肠道排空时间内(3-6h)酶解完全。结论所制备的淫羊藿总黄酮仿生酶解肠溶胶囊有利于促进淫羊藿总黄酮在体内的水解转化,为研发高效的淫羊藿总黄酮新制剂提供研究基础。
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| 关 键 词： | 淫羊藿总黄酮 蜗牛酶 肠溶胶囊 仿生酶解 黄酮苷 淫羊藿苷 朝藿定A 朝藿定B 朝藿定C |
| 收稿时间： | 2016-05-05 |
Preparation and evaluation of bionic enzymatic Epimedium flavonoids-loaded enteric-coated capsules |
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| LIU Cong-yan,GAO Xi,HUANG Meng-meng,PENG Jing and CHEN Yan. Preparation and evaluation of bionic enzymatic Epimedium flavonoids-loaded enteric-coated capsules[J]. Chinese Traditional and Herbal Drugs, 2016, 47(20): 3610-3617 |
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| Authors: | LIU Cong-yan GAO Xi HUANG Meng-meng PENG Jing CHEN Yan |
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| Affiliation: | Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China;Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China;Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China;Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China;Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China;Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China |
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| Abstract: | |
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| Keywords: | Epimedium flavonoids snailase enteric-coated capsules bionic enzymolysis flavone glycosides icariin epimendin A epimendin B epimendin C |
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