洋金花化学成分和药理作用及临床应用研究进展

洋金花为《中国药典》2015年版收载品种,具有重要的药用价值。洋金花中的主要化学成分包括醉茄内酯类、黄酮类、生物碱类、倍半萜类以及酚酸类和木脂素类等化合物。现代药理学研究表明,洋金花具有抗炎、抗瘙痒、细胞保护以及抗菌、抗氧化等药理作用,而且其对上皮细胞有丝分裂及皮肤角化、中枢神经系统、心血管系统、呼吸系统也有一定的影响。洋金花临床上多用于治疗银屑病、慢性支气管炎、哮喘、小儿肺炎、帕金森病、风湿等疾病。综述洋金花的化学成分、药理作用及临床应用研究进展,以期为洋金花的深入研究和开发利用提供参考。

Research progress in chemical constituents, pharmacological effects, and clinical applications of Daturae Flos

Daturae Flos (flowers of Datura metel) is recorded by Chinese Pharmacopoeia for its important medicinal property. The most characteristic chemical constituents in Daturae Flos are withanolides, flavonoids, and alkaloids. There are also sesquiterpenoids, phenolic acid, and lignans in it. Daturae Flos has various pharmacological activities, such as anti-inflammation, anti-itching, cytoprotection, antibacterial effects, antioxidation, and so on. Daturae Flos also has the effect on epithelial cells mitosis and skin keratinization, immune system, central nervous system, cardiovascular system, and respiratory system. It is usually used to treat psoriasis, chronic tracheitis, asthma, infantile pneumonia, Parkinson disease, and rheumatism. In this paper, we summarize the chemical composition, pharmacyological effects, and clinical curative effect of Daturae Flos to prompt the development and utilization of them.