Behavior in chimeric mice combining differently behaving strains |
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| Authors: | Muriel N. Nesbitt M. Anne Spence Karla Butler |
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| Affiliation: | (1) Department of Biology, B-022, University of California at San Diego, 92093 La Jolla, California;(2) Departments of Psychiatry and Biomathematics, University of California at Los Angeles, 90024 Los Angeles, California;(3) Department of Psychology, California State University, Northridge, 91324 Northridge, California |
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| Abstract: | A/J and C57BL/6J mice behave differently in tests for alcohol preference, open-field activity, defecation in the open field, cricket attacking, and rope climbing. Chimeric mice, i.e., mice containing both A/J cells and C57BL/6J cells, were constructed and tested for these behaviors. Patterns of behavior among A/J C57BL/6J chimeras are such as to suggest that none of these behavior differences is controlled by a single cell or clone and that the same cell population that gives rise to the strain difference in alcohol preference also gives rise to the differences in open-field activity and defecation, while separate cell populations control cricket killing and rope climbing.This research was supported by Research Grants AA 00388 and HD 03015 to M. N. N. and MH 18996 to K. B. Computing assistance was obtained from the Health Sciences Computing Facility, UCLA, supported by NIH Special Research Resources Grant RR-3. |
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| Keywords: | inbred strains of mice C57BL mice A mice chimera alcohol preference open field activity open field defecation cricket attacking rope climbing factor analysis |
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