胃癌危险性不同人群膳食硝酸盐、亚硝酸盐及维生素C摄入量

本文研究福建省长乐县胃癌危险性不同的人群膳食硝酸盐(NO_3~-)、亚硝酸盐(NO_2~-)及维生素C摄入量。胃癌死亡率较高的漳港乡居民NO_3~-摄入量(132.75mg/日)明显高于死亡率居中的首占乡(84.65mg/日)(P<0.05),但与死亡率较低的梅花乡(113.12mg/日)无显著性差异。NO_2~-摄入量漳港乡显著高于首占乡和梅花乡(3.36mg/日对0.21和0.73mg/日)(P<0.01)。首占乡居民维生素C摄入量(56.13mg/日)明显低于漳港乡(123.09mg/日)和梅花乡(105.90mg/日)(P<0.01)。维生素C摄入量与NO_2~-摄入量的摩尔比值三个乡分别为3.22、3.30和4.33,与胃癌死亡率呈相反平行关系。结果提示:NO_3~-和NO_2~-可能是该地区胃癌高发的因素之一。

DAILY DIETARY INTAKES OF NITRATE, NITRITE AND VITAMIN C IN POPULATIONS AT DIFFERENT RISK OF GASTRIC CANCER

Daily dietary intakes of nitrate, nitrite and vitamin C were investigated in Chanle county, Fujian province, where gastric cancer was very common, with a marked geographic variation in mortality. The average daily intake of nitrate of residents in Zhanggang village (high risk area) was 132.75 mg, which was significantly higher than that (84.65 mg) in Shouzhan village (moderate risk area), but similar to that (113.12 mg) in Meihua village (low risk area). However, nitrite intake in Zhanggang village was greatly higher than that in Shouzhan and Meihua villages (3.36 mg vs 0.21 and 0.37 mg, respectively). The average daily intake of vitamin C in Shouzhan village was 56.37 mg, significantly lower than that in Zhanggang village (123.09 mg) and in Meihua village (105.90 mg). The molar ratio of vitamin C intake to nitrite in the three villages was 3.22, 3.30 and 4.33, respectively. It was invesely associated with the mortality of gastric cancer. The results suggested that nitrate and nitrite might be etiological factors of gastric cancer in the county.