糖化血红蛋白与糖尿病视网膜病变的关系研究

目的探讨糖化血红蛋白(HbA1C)、空腹血糖(FBG)与2型糖尿病视网膜病变的关系。方法对89例2型糖尿病患者进行HbA1C、FBG检测及眼底检查或荧光素造影检查。其中糖尿病正常眼底(NDR)组49例,糖尿病视网膜病变(DR)组40例。结果 HbA1C水平有糖尿病视网膜病变组较无视网膜病变组高(t=5.310,P0.01),HbA1C水平越高,视网膜病变发生率越高(χ2=12.59,P0.05),HbA1C≥7%时视网膜病变发生率明显升高;而FBG水平DR组与NDR组差异无统计学意义(t=0.438,P0.05)。结论 HbA1C测定可作为DR发生、发展的重要指标,且将HbA1C控制在7%以下,对预防糖尿病视网膜病变的发生和发展极为重要,降低糖化血红蛋白水平有助于降低视网膜病变的危险。

Research on the Relationship between Glycated Hemoglobin and Diabetic Retinopathy

Objective To explore the roles of glycated hemoglobin （HbA1C） and fasting blood glucose （FBG）in the process of type 2 diabetic retinopathy. Methods 89 type 2 diabetes patients were selected to receive HbA1C and FBG testing as well as fundus examination or fluorescein angiography. 40 cases and 49 controls were included in this study.Results The HbA1C level of diabetic retinopathy group was proved to be higher than that in non-diabetic retinopathy group （t=5.310,P〈0.01）,the incidence of retinopathy increased with the rise of HbA1C level （χ^2=12.59,P〈0.05）,especially when HbA1C reached to 7.0%,but there was no significant difference about FBG level between the two groups （t =0.438,P〈0.05）. Conclusion HbA1C could be used as a key indicator in the occurrence and development of diabetic retinopathy,and a good control of HbA1C level（HbA1C7%）was critical to prevent the occurrence and development of diabetic retinopathy. Reducing the HbA1C level helped decrease the risk of retinopathy.