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| 麻杏石甘提取物对模型大鼠抗哮喘作用机制研究 | |
| 引用本文： | 陈玥,尉小慧,孙秀梅,张兆旺. 麻杏石甘提取物对模型大鼠抗哮喘作用机制研究[J]. 中国药房, 2006, 17(19): 1457-1459 |
| 作者姓名： | 陈玥 尉小慧 孙秀梅 张兆旺 |
| 作者单位： | 1. 南京工业大学材料科学与工程学院,南京市,210009 2. 上海中药标准化研究中心,上海市,201203 3. 山东中医药大学,济南市,250014 |
| 基金项目： | 山东省中医药管理局资助项目 |
| 摘 要： | 目的研究麻杏石甘提取物(ME)对哮喘模型大鼠抗哮喘作用的机制。方法复制卵清蛋白致敏哮喘大鼠模型,观察ME对大鼠体重、引喘潜伏期、白细胞计数及分类、血液与肺组织中内皮素-1(ET-1)含量及肺部病理学改变的影响。结果ME对哮喘模型大鼠有增加体重,延长引喘潜伏期,恢复机体的白细胞数目及正常分布,降低血及肺组织中ET-1含量,改善肺部支气管组织病理形态学结构等作用。结论抑制ET-1的释放可能为ME抗哮喘作用机制之一。 |
| 关 键 词： | 麻杏石甘提取物 大鼠 哮喘 白细胞 内皮素-1 |
| 文章编号： | 1001-0408(2006)19-1457-03 |
| 收稿时间： | 2005-12-01 |
| 修稿时间： | 2006-03-07 |
Study on the Anti - asthma Mechanism of Action of Maxing Shigan Extract on Asthma Model Rats |
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| CHEN Yue,WEI Xiaohui,SUN Xiumei,ZHANG Zhaowang. Study on the Anti - asthma Mechanism of Action of Maxing Shigan Extract on Asthma Model Rats[J]. China Pharmacy, 2006, 17(19): 1457-1459 | |
| Authors: | CHEN Yue WEI Xiaohui SUN Xiumei ZHANG Zhaowang |
| Abstract: | OBJECTIVE:To investigate the anti-asthma mechanism of Maxing shigan extract (ME) on the asthma model rats.METHODS:Rats models of asthma were induced with egg albumin,the indexes of weight,cough incubation period,leukocytes'count and classification in the blood,ET-1 content in the blood and the lung tissue,and lung's pathological struc_ture of the asthma rats were detected. RESULTS: ME could increase the weight,prolong the cough incubation period,help to normalize the count and distribution of leukocytes,reduce the ET-1 content in the blood and the lung tissue,and improve the bronchi's and the lung's pathological structure of the asthma rat.CONCLUSION: It may be one of the anti-asthma mechan_isms of ME that it inhibits the release of ET-1. |
| Keywords: | Maxing shigan extract Rat Asthma Leukocytes ET- 1 |
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