Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participants. |
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Authors: | Roy H Perlis Melissa P Delbello Sachiko Miyahara Stephen R Wisniewski Gary S Sachs Andrew A Nierenberg |
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Affiliation: | Bipolar Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. rperlis@partners.org |
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Abstract: | BACKGROUND: We examined the hypothesis that a first depressive rather than manic episode in bipolar disorder might herald a subsequent course notable for greater burden of depressive symptoms. METHODS: We analyzed retrospective data on the polarity of first mood episode obtained from 704 bipolar I subjects entering the multicenter Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study. Subjects with an initial manic or depressive episode and those in whom both poles occurred within the same year were compared. RESULTS: Depressive-onset bipolar disorder was more common in women and those with earlier onset of illness. Adjusting for these differences, it was significantly associated with more lifetime depressive episodes and a greater proportion of time with depression and anxiety in the year prior to study entry. CONCLUSIONS: Polarity of first mood episode may be useful in distinguishing subsets of bipolar patients at risk for a more chronic course. |
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Keywords: | Bipolar disorder depression age of onset polarity chronic |
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