| EB病毒抗体联合检测在鼻咽癌血清学诊断和筛查中的应用评价 |
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| 引用本文： | 李筱莉,陈燕,叶倩,刘秀琴. EB病毒抗体联合检测在鼻咽癌血清学诊断和筛查中的应用评价[J]. 检验医学与临床, 2011, 8(2): 140-141,144. DOI: 10.3969/j.issn.1672-9455.2011.02.006 |
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| 作者姓名： | 李筱莉 陈燕 叶倩 刘秀琴 |
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| 作者单位： | 福建医科大学附属福建省肿瘤教学医院检验科,福州,350014 |
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| 摘 要： | 目的探讨单项和联合检测EB病毒(EBV)VCA-IgA、EA-D-IgG和EA-D-IgA 3种抗体在鼻咽癌血清学诊断及筛查中的价值。方法收集300例鼻咽癌患者血清,选择鼻咽良性疾病91例及可能与EB病毒感染有关的其他癌症患者100例为对照研究对象。用酶联免疫吸附试验(ELISA)对所有患者同时检测血清EBV VCA-IgA、EA-D-IgG和EA-D-IgA 3种抗体,评价单项和联合检测EB病毒抗体对鼻咽癌的血清学诊断和筛查的价值。结果单项EB抗体对鼻咽癌诊断的敏感性和特异性分别为:VCA-IgA 82.0%、85.7%,EA-D-IgG 84.6%、95.6%,EA-D-IgA 44.0%、97.8%,平行联合检测VCA-IgA和EA-D-IgG的敏感性为97.2%,大大高于各单项EBV抗体检测结果,差异有统计学意义(P<0.05),阴性预测值也高于VCA-IgA和EA-D-IgA,差异也有统计学意义(P<0.05)。结论联合检测EBVCA-IgA和EA-D-IgG有互补作用,二者平行联合检测可提高鼻咽癌血清学诊断及筛查的敏感性,序列联合检测可提高鼻咽癌血清学筛查的特异性。
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| 关 键 词： | 鼻咽肿瘤/诊断 抗体 病毒 疱疹病毒4型 人 普查 |
Applicational value of combination detection of antibodies against Epstein-Barr virus in serological diagnosis and screening of nasopharyngeal carcinoma |
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| LI Xiao-li,CHEN Yan,YE Qian,LIU Xiu-qin. Applicational value of combination detection of antibodies against Epstein-Barr virus in serological diagnosis and screening of nasopharyngeal carcinoma[J]. Laboratory Medicine and Clinic, 2011, 8(2): 140-141,144. DOI: 10.3969/j.issn.1672-9455.2011.02.006 |
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| Authors: | LI Xiao-li CHEN Yan YE Qian LIU Xiu-qin |
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| Affiliation: | LI Xiao-li,CHEN Yan,YE Qian,LIU Xiu-qin(Department of Clinical Laboratory,Affiliated Fujian Tumor Hospital,Fujian Medical University,Fuzhou 350014,China) |
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| Abstract: | Objective To investigate the value of combinational or separate detection of three antibodies against Epstein-Barr virus(EBV) VCA-IgA,EA-D-IgG and EA-D-IgA by enzyme-linked immunosorbent assay(ELISA) in the serological diagnosis and screening of nasopharyngeal carcinoma(NPC).Methods We measured VCA-IgA,EA-D-IgG and EA-D-IgA expression in 300 serum specimens of NPC,91 serum specimens of benign nasopharyngeal diseases and 100 serum specimens of cancer by ELISA.To analyze the applicational value of combination... |
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| Keywords: | nasopharyngeal neoplasms/diagnosis antibodies viral herpesvirus 4 human mass screening |
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