乙型肝炎病毒前S1抗原和HBV—DNA的相关性分析

目的探讨乙肝病毒前S1抗原与乙肝病毒脱氧核糖核酸（HBV—DNA）的相关性以及前S1抗原检测的临床意义。方法检测381例乙肝患者前S1抗原和HBV—DNA定量。结果132例乙肝表面抗原（HBeAg）阳性患者血清中前S1抗原阳率89．4％，HBV～DNA阳性率91．7％；218例乙肝e抗体（抗－HBe）阳性患者血清中前S1抗原阳性率30．7％，HBV—DNA阳性率27．1％；31例HBeAg和抗－HBe均为阴性，乙肝患者中前S1抗原阳性率38，7％，HBV—DNA阳性率41．9％。前S1抗原与HBV—DNA符合率为92．4％。结论前S1抗原与HBV—DNA符合率较高，可以作为乙肝病毒感染复制的重要指标。

Analysis of correlation between HBV Pre-S1 antigen and HBV-DNA

Objective To explore the diagnostcc value of HBV Pre - S1 antigen and correlation with HBV - DNA. Methods For the 381 cases with hepatitis B virus infection, measure HBV Pre - S1 antigen with ELISA and HBV - DNA quantitative with PCR. Results The positive rate of HBV Pre - S1 antigen was 89.4% and HBV - DNA was 91.7% in 132 cases with HbeAg positive . The positive rate of HBV Pre - S1 antigen was30.7% and HBV - DNA was27.1% in 218 eases with anti - Hbe positive. The positive rate of HBV Pre - S1 antigen was38.7% and HBV - DNA was 41.9% in 31 Cases with HbeAg and anti - Hbe were negative, The coincident rate was 92.4% between Pre - S1 antigen and HBV - DNA. Conclusion Bewtten of Pre - S1 antigen and HBV - DNA was highly matched. It can be used as valuabte index for hepatitis B virus infection and replication.