Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm |
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Authors: | Kenichi Hirabayashi Giuseppe Zamboni Hiroyuki Ito Masami Ogawa Yoshiaki Kawaguchi Tomohiro Yamashita Toshio Nakagohri Naoya Nakamura |
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Institution: | Department of Pathology,Tokai University School of Medicine,Isehara 259-1193,Japan;Department of Pathology,Ospedale Sacro Cuore Don Calabria,37024 Negrar Verona,Italy;Department of Pathology,University of Verona,37134 Negrar Verona,Italy;Department of Gastroenterology,Tokai University School of Medicine,Isehara 259-1193,Japan;Department of Radiology,Tokai University School of Medicine,Isehara 259-1193,Japan;Department of Gastroenterological Surgery,Tokai University School of Medicine,Isehara 259-1193,Japan |
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Abstract: | Solid pseudopapillary neoplasm (SPN) is a rare and low-grade malignant pancreatic neoplasm composed of poorly cohesive monomorphic neoplastic cells forming solid and pseudopapillary structures with frequent hemorrhagic-cystic degeneration. Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic exocrine tumor composed of intraductal papillary growth of mucin containing neoplastic cells in the main pancreatic duct or its major branches. In the case presented here, a 53-year-old, Japanese man was found to have multiple cystic lesions and dilatation of the main pancreatic duct in the neck of the pancreas. Histological examination revealed a main-duct and branch-duct type IPMN, of the gastric-type, involving the neck of the pancreas, associated with a 0.5 cm SPN in the caudal side of the IPMN. We diagnosed this case as synchronous SPN and IPMN. As far as we know, only one other case of synchronous SPN and IPMN has been reported. Both the present case and the previously reported case showed abnormal nuclear expression of β-catenin in SPN, whereas IPMN showed no abnormal nuclear expression. These results suggest that β-catenin abnormality is not a common pathogenetic factor of synchronous SPN and IPMN. |
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Keywords: | Intraductal papillary mucinous neoplasms Solid pseudopapillary neoplasms Pancreatic neoplasms Synchronous neoplasms Pancreas Beta-catenin |
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