| 内蒙古地区汉族人群HLA-DQB1基因多态性与支气管哮喘相关性研究 |
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| 引用本文： | 年英,崔丽英. 内蒙古地区汉族人群HLA-DQB1基因多态性与支气管哮喘相关性研究[J]. 内蒙古医学院学报, 2013, 0(5): 372-375 |
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| 作者姓名： | 年英 崔丽英 |
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| 作者单位： | 内蒙古医科大学附属医院呼吸内科,内蒙古呼和浩特010050 |
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| 基金项目： | 内蒙古自治区自然科学基金项目（20080404MS1104） |
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| 摘 要： | 目的：探讨内蒙古地区汉族人群中人类白细胞抗原HLA-DQB 1基因多态性与支气管哮喘的相关性。方法：采用序列特异性引物聚合酶链反应（ PCR-SSP）法对50例汉族哮喘病人与50例汉族健康者进行人类白细胞抗原HLA-DQB 1等位基因频率检测。结果：汉族支气管哮喘HLA-DQB 10602基因频率高于汉族健康对照组（P〈0.01,OR=6.163）。结论：HLA-DQB 10602基因可能是内蒙古地区汉族支气管哮喘病人的易感基因。
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| 关 键 词： | 哮喘 白细胞抗原 汉族 |
CORRELATIONS BETWEEN HUMAN LEUKOCYTE ANTIGEN DQB 1 GENE POLYMORPHISMS AND BRONCHIAL ASTHMA IN THE INNER MONGOLIA REGOIN |
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| NIAN Ying,CUI Li-ying. CORRELATIONS BETWEEN HUMAN LEUKOCYTE ANTIGEN DQB 1 GENE POLYMORPHISMS AND BRONCHIAL ASTHMA IN THE INNER MONGOLIA REGOIN[J]. Acta Academiae Medicinae Neimongol, 2013, 0(5): 372-375 |
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| Authors: | NIAN Ying CUI Li-ying |
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| Affiliation: | ( Department of Respiratory ,Afflicted Hospital, Inner Mongolia Medical University, Hohhot 010050 China ) |
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| Abstract: | Objective：To investigate the association between Human Leukocyte antigen DQB1 （ HLA-DQB1 ） gene polymorphisms and Bronchial asthma of Han nationality. Methods：Sequence-specific primer polymerase chain reaction（ PCR-SSP） was used to detect gene frequencies of HLA DQB 1 alleles in 50 cases of Han asthmatic patients and 50 health Han controls. Results：HLA-DQB 10602 allele were higher in bronchial asthma of Han than in healthy Han nationality（P〈0. 01,OR=6. 163）. Conclusions：HLA-DQB 10602 allele may be a susceptive gene of bronchial asthma in Han nationality in the Inner Mongolia Region. |
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| Keywords: | asthma HLA antigens Han nationality |
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