1448例妇科患者HPV感染型别分布及临床分析

目的分析女性HPV感染的阳性率和各年龄段的关系及常见亚型的分布情况，探讨女性HPVDNA基因分型技术检测在宫颈癌防治方面的应用价值。方法采用HPV基因分型技术对1448例妇科门诊就诊者进行HPV分型检测。结果1448例样本中，检出HPV阳性者531例，总阳性率为36．7％，其中高危型HPV468例，占感染率88％，低危型HPV63例，占感染率12％，混合感染HPV122例，占感染率23％，HPV基因型单一感染为77．2％，二重感染为17．9％，三重感染为3．6％，四重感染为1．5％。高危型中未检出HPV35、73、83、MM4型，低危型中未检出HPV43、44型。患者其亚型感染率由高到低依次为HPV58、16、52、33、18、31、53、68、66、51、39、56和59型，低危型依次为HPV11、6、42型。不同年龄组中HPV感染高峰在50～59岁和60～69岁这两个年龄段，感染率分别为78．9％和73．7％。结论HPV感染型别普遍化，各年龄段感染的阳性率差异有统计学意义（P〈0．05），25岁前后及〉50岁的妇女更应予以重视，对阳性患者要加强定期随访，HPV基因分型及多种亚型的检测有利于宫颈癌的早期预警和早期治疗。

Clinical analysis of 1448 cases of gynecological patients with type HPV infection

Objective Analysis of the distribution of positive rate of HPV infection between the female and the age and common subtypes. To explore the application value of female HPV DNA genotyping detection in cervical cancer prevention. Methods Typing of 1448 patients with gynecological outpatients for HPV typing detection by HPV gene. Results In 1448 cases, 531 cases were HPV positive, the total positive rate was 36.7% , which accounted for high-risk HPV468 patients, the infection rate was 88% , the low risk HPV63 patients, accounted for the infection rate was 12% , HPV122 cases of mixed infection, infection rate was 23% , HPV genotype 77.2% infection for single, double infection was 17.9% , three heavy infection was 3.6% , four serious infection was 1.5%. HPV35 was not detected, 73, 83, MM4 type high risk, low risk type was not found in HPV43, type 44. The subtype infection rate from high to low is HPV58, 16, 52, 33, 18, 31, 53, 68, 66, 51, 39, 56 and 59, low risk types were HPVll, 6, 42. The peak in 50-59 and 60-69 years old in the two age of HPV infection in different age groups, infection rates were 78.9% and 73.7%. Conclusion The infection of HPV type universal, there was statistically significant difference of positive rate of each age infection （ P 〈 0. 05 ） , before and after the age of 25 and women 〉50 years of age should be paid more attention to the positive patients, to strengthen the regular follow-up, the detection of HPV genotypes and subtypes in favor of cervical cancer early warning and early treatment.