囊性肾癌组织p73、p53和Ki67的表达及其临床意义

目的 探讨抑癌基因p73、p53和Ki67表达水平对囊性肾癌患者的分级和预后的影响.方法 采用免疫组织化学检测2010年1月至2015年1月60例囊性癌组织和40例正常组织中的p73、p53和Ki67蛋白表达水平,并比较其表达水平和癌症分级、预后等病理参数的关系.结果 囊性肾癌组织中p73、p53、Ki67阳性表达分别为48例、47例、51例,显著高于正常组织的3例、0例和2例(P<0.01).不同分化程度(8例、27例、16例)、分期(10例、19例、13例、9例)、转移(26例、25例)和预后(29例、22例)的癌组织中Ki67表达水平差异有统计学意义(P<0.05).不同分化程度(7例、26例、15例)和分期(8例、18例、13例、9例)的癌组织中p73表达水平差异有统计学意义(P<0.05).p53和p73、Ki67表达水平无相关性(r=0.098,r=0.849,P>0.05),p73、Ki67表达水平呈正相关性(r=8.366,P<0.05).结论 p73和Ki67参与了囊性肾癌的分级和分期,但对预后的影响各有不同.

Expression and clinical significance of p73, p53 and Ki67 in cystic renal cell carcinoma

Objective To investigate the effects of p73, p53 and Ki67 expression levels on the classification and prognosis of cystic renal cell carcinoma. Methods During the period January 2010 through January 2015, immuno-histochemistry was used to detect the expression of p73, p53 and Ki67 in 60 cases with cystic carcinoma tissue and 40 cases with normal tissues. The possible relationships between the expression level and the pathological parameters such as cancer classification, prognosis were analyzed. Results The positive expression of p73, p53 and Ki67 in the cystic renal cell carcinoma (48, 47, 51, respectively) were significantly higher than (3, 0, 2) in healthy control (P<0.01). There were statistically significant differences in the expression of Ki67 in different degrees of differentiation (8, 27, 16), stage (10, 19, 13, 9), metastasis (26, 25) and prognosis (29, 22) of cystic renal cell carcinoma tissues (P<0.05). There were al-so statistically significant differences in the expression of p73 in different degrees of differentiation (7, 26, 15) and stages (8, 18, 13, 9) of cystic renal cell carcinoma tissues (P<0.05). The expression level of p53 was not correlated with p73 and Ki67 expression levels (r=0.098, r=0.849, P>0.05), and p73 expression level was positively correlated with Ki67 (r=8.366, P<0.05). Conclusion p73 and Ki67 are involved in the grading and staging of cystic renal cell carcinoma, and there are different effects on the prognosis.