妊娠妇女不同孕周的外周血雌二醇动态水平分析

目的 动态观察妊娠妇女不同孕周的外周血雌二醇水平,评估其对妊娠结局的预测作用.方法 选取2012年1月至2014年12月期间我院接诊的3901例孕4~15周的妊娠妇女为研究对象,在征得妊娠妇女同意的原则下进行外周血雌二醇的动态监测,分析不同孕周期间雌二醇水平波动状况,并通过SPSS18.0软件进行统计分析各孕周的外周血雌二醇范围,评估不同孕周雌二醇水平对妊娠结局的预测能力.结果 3901例妊娠妇女不同孕周的外周血雌二醇水平随着孕周的增加而缓慢上升,其均值水平从第4周的253 pg/mL开始增长,至第12周达到最高峰1975 pg/mL,13周之后有所回落;而各孕周间增幅高低也不一,其均值水平从第1周间增长106 pg/mL开始增长至第3周间达到增幅376 pg/mL,然后出现增幅变缓,在小于12周前期间平均增值246 pg/mL,在大于或等于13周略有向上波动,但总体呈现下降趋势.结论 妊娠妇女不同孕周的外周血雌二醇水平与妊娠密切相关,可以作为预测妊娠结局的重要指标,尤其在12周前,其增长速度与孕周呈正相关性.

Analysis of the dynamic level of estradiol in the peripheral blood of pregnant women with different gestational weeks

Objective To observe the level of estradiol in the peripheral blood of pregnant women at the differ-ent gestational weeks, and to evaluate the outcome of pregnancy. Methods A total of 3901 pregnant women with 4~15 weeks of pregnancy in our hospital from January 2012 to December 2014 were enrolled in the study. The dynamic moni-toring of estradiol was performed to analyze the fluctuation of estradiol levels in different pregnant periods. The range of estradiol in the peripheral blood was analyzed by SPSS18.0 software in order to evaluate the predictive role of estradiol levels in different gestational weeks on the outcome of pregnancy. Results In the 3901 pregnant women, the levels of estradiol increased slowly with the increase of the gestational weeks, and the mean levels began to grow from 253 pg/mL in the fourth week to the peak of 1975 pg/mL in the twelfth week, which then tended to fall after 13 weeks of gestation. The increased levels of different gestational weeks were different, and the increase amplitude of mean levels increased from 106 pg/mL in the first week to 376 pg/mL in the third week, and then started to slow down or even fall back. The average increase amplitude was 246 pg/mL in the period of less than 12 weeks, and the levels after 13 weeks generally showed a downward trend with slightly upward fluctuations. Conclusion The level of estradiol in the pregnant women is closely related with the pregnancy in different gestational weeks. It can be used as an important index to predict the outcome of pregnancy, especially before 12 weeks.