胸腔积液可溶性髓系细胞触发受体1水平及意义

目的 探讨各种病因所致胸腔积液可溶性髓系细胞触发受体1(sTREM-1)的水平及意义.方法 分别收集细菌性胸腔积液(n=12)、结核性胸腔积液(n=31)、恶性肿瘤胸腔积液(n=35)和漏出液(n=15)患者的胸水和外周血标本,采用酶联免疫吸附测定法检测胸水和血清中sTREM-1的浓度.结果 4种类型的胸腔积液其胸水sTREM-1浓度均高于血清sTREM-l浓度(P＜0.05或＜0.01).细菌性胸腔积液其胸水和血清sTREM-l浓度均明显高于结核性胸腔积液、恶性肿瘤胸腔积液和漏出液,胸水sTREM-1M(QR)]2 616.9(2 096.8)ng/L vs 286.0(348.0)ng/L、496.8(1 160.5)ng/L、102.3(266.5)ng/L(P＜0.01),血清sTREM-1 38.1(28.1)ng/L vs 0.2(19.8)ng/L、0.0(14.3)ng/L、15.7(67.6)ng/L(P＜0.01).结论 胸膜疾病胸腔积液TREM-1表达水平增高,以胸膜细菌感染时增高最明显,胸水sTREM-1浓度可以作为判断细菌感染的参考指标.

Significance of soluble triggering receptor expressed on myeloid cells-1 in pleural effusions of various causes

Objective The aim of this study was to investigate the expression of soluble triggering receptor expressed on myeloid cells-1（sTREM1） in pleural effusions of various causes and their significations.Methods Enzyme-linked immunosorbent assay was used to measure the pleural fluid and peripheral blood concentration of sTREM-1 from patients with infectious pleural effusion（n=12）,tuberculous pleural effusion（n=31）,neoplastic pleural effusion（n=35） and transudate（n=15）.Results The concentrations of sTREM-1 in four kinds of disease pleural effusions were significantly higher than those in corresponding peripheral blood（P〈0.05 or〈 0.01）.The levels of sTREM-1 in both bacterial infectious pleural effusion and corresponding eripheral blood were the highest in all groups,the median 2 616.9（2 096.8） ng/L vs 286.0（348.0） ng/L,496.8（1 160.5） ng/L,102.3（266.5） ng/L（P〈0.01）.The level of sTREM-1 in corresponding peripheral blood was arranged as 38.1（28.1） ng/L vs 0.2（19.8） ng/L,0.0（14.3） ng/L,15.7（67.6） ng/L（P〈0.01）.Conclusion TREM-1 expression was increased in the disease of pleura.While the level of sTREM-1 in bacterial infectious pleural effusion was the highest in all causes.The concentration of sTREM-1 in pleural effusions may be a diagnosis index for bacterial infection.