| 鼻咽癌变过程中DNA依赖蛋白激酶表达水平研究 |
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| 摘 要： |
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| 关 键 词： | 鼻咽炎 鼻咽癌前期损害 癌发生 临床研究 |
| 收稿时间： | 14 November 2010 |
Expression of DNA-dependent protein kinase in the nasopharyngeal tissue during carcinogenesis |
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| Authors: | Xiaojun Zhou Shuqin Wang Shizhen Wang Yan Ruan Ruixia Xuan Peng Liu Baoshan Qiu |
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| Institution: | [1]Department of Otorhinolaryngology, The Zhongshan Affiliated Hospital Guangzhou University of Traditional Chinese Medicine, Zhongshan 528400, China [2]Department of Otorhinolaryngology, The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China |
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| Abstract: | Objective:To observe the expression of DNA-dependent protein kinase (DNA-PKcs) in the nasopharyngeal tissues during carcinogenesis.Methods:Patients including 30 cases of nasopharyngitis,42 cases of nasopharyngeal atypical hyperplasia and 34 cases of nasopharyngeal carcinoma (NPC) were chosen from Zhongshan area in which there is high incidence rate of NPC.The expression of DNA-PKcs in the nasopharyngeal tissue was examined by immunohistochemistry.Results:The expression rates of DNA-PKcs in the nasopharyngitis tissue,the nasopharyngeal precancerous lesion and the NPC were 6.7%,64.3% and 55.9%,respectively (P＜0.001).Conclusion:The expression of DNA-dependent protein kinase may play an important role in nasopharyngeal tissue carcinogenesis. |
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| Keywords: | nasopharyngitis nasopharyngeal precancerous lesion nasopharyngeal carcinoma DNA-dependent protein kinase (DNA-PKcs) clinical study |
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