再生障碍性贫血患者血清白细胞介素—3检测及其临床意义

目的 检测再生障碍性贫血（再障）患者血清白介素－3（IL－3）水平并探讨其意义。方法 采用酶联免疫法。结果 测定50例再障患者（慢性再障40例，重型再障10例）血清IL－3水平，18例高于正常（P＜0．01），其中慢性再障10例，重型再障8例；IL－3水平升高的再障患者CFU－GM数明显低于IL－3水平正常的患者（P＜0．05）。IC－3升高的再障患者同IL－3正常者疗效无差异（P＞0．05），而治疗有效的IC－3升高患者治疗后IL－3水平明显降低（P＜0．05）。结论 再障患者IC－3水平的检测有助于判定疾病的严重程度，为治疗提供指导。

Detection of serum interleukin-3 level and its clinical significance in aplastic anemia patiens.

Objective To investigate the clinical significance of serum interleukin 3(IL 3)detection in aplastic anemia(AA)patients Methods Serum level of IL 3 in 50 patients with AA detected by enzymelinked immunosorbent assay(ELISA) Results The levels of serum IL 3 in 18 out of 50 AA patients were higher than that of control( P<0 01 ),including 8 severe AA(SAA) patients and 10 chronic AA(CAA) cases Numbers of CFU GM were lower in the AA patients whose IL 3 levels were higher( P<0 05 ) There was no statistical signiicance in treatment efficacy between the patients whose serum IL 3 levels were above normal and those of normal( P>0 05) The level of serum IL 3 decreased significantly after achiered curative outcomes in the patients whose IL 3 levels were higher( P<0 05 ) Conclusion Detection of serum IL 3 in AA patients is helpful for judging the severity of disease and providing information of therapy