低剂量粒生素对恶性肿瘤化疗所致白细胞减少的临床疗效观察

 目的　评价低剂量粒生素对恶性肿瘤化疗所致白细胞减少的疗效。方法　采用每天皮下注射粒生素 75μg一次治疗 45例因恶性肿瘤化疗所致白细胞减少的患者 ,他们治疗前外周血白细胞总数平均值为 ( 1 .85± 2 .66)× 1 0 9/ L。结果　 45例患者治疗后外周血白细胞总数上升达显效( 1 8例 )或有效 ( 2 4例 )所需时间为 5.5± 4.8d,有效率 93.33% ;无效 3例 ,占 6.67%。结论　每天皮下注射低剂量粒生素 ( 75μg/ d,可以明显减轻化疗过程中外周血白细胞下降程度、缩短白细胞在4.0× 1 0 9/ L以下的持续时间及恢复到 4.0× 1 0 9/ L以上的时间 ,且毒副反应轻微、安全可靠、费用较低 ,值得临床推广应用.

Observation of using low-dose Lishengsu for the Leukocyte reducing in Malignant Tumor Chemotherapy

Objective To appraise the curative effect of using low dose lishengsu for the leukocyte reducing in malignant tumor chemotherapy. Methods The rhG CSF(Lishegsu) at a dose of 75μg/body•day was given subcataneously for forty five patients with the leukocyte reducing in malignant tumor chemotherapy,and their average leukocyte count were(1.85±2.66)×10 9/L before receiving the treatment.Results The time of fory five patients s circum leukocyte count upawing to availability(18 cases)or producing effects,was...