| 高效液相色谱法测定复方妥英麻黄茶碱胶囊中苯妥英钠的含量 |
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| 引用本文： | 侯小虎,;梁泰刚,;李青山,;王建平. 高效液相色谱法测定复方妥英麻黄茶碱胶囊中苯妥英钠的含量[J]. 中国药物与临床, 2014, 0(12): 1643-1645 |
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| 作者姓名： | 侯小虎, 梁泰刚, 李青山, 王建平 |
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| 作者单位： | [1] 山西医科大学第三医院药剂科,太原030053; [2] 山西医科大学药学院;,太原030053; [3] 山西省第二人民医院药剂科,太原030053; |
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| 摘 要： | 目的建立高效液相色谱法测定复方妥英麻黄茶碱胶囊中苯妥英钠的含量。方法采用Diamonsil钻石C18(150 mm×4.6 mm,5μm)色谱柱,以甲醇-水(50∶50)为流动相,检测波长为215 nm,流速为1.0ml/min,柱温设置为室温。结果 3批复方妥英麻黄茶碱胶囊及片剂的标示量为97.88%(20121202)、99.56%(20121203)、96.41%(20121204),102.9%(片剂)。结论本方法简便,结果准确可靠,可用于该制剂质量控制的有效方法。
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| 关 键 词： | 药用制剂 质量控制 色谱法,高压液相 复方妥英麻黄茶碱胶囊 含量 |
Determination of the phenytoin content in Compound Theophylline and Ephedrine Capsules by HPLC |
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| Affiliation: | Hou Xiaohu, Liang Taigang, Li Qingshan, Wang Jianping(Department of Pharmacy the Third Hospital of-Shanxi Medical University, Taiyuan 030053, China) |
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| Abstract: | Objective To establish the determination of the content of phenytoin in Compound Theophylline and Ephedrine Capsules by high performance liquid chromatography （HPLC）. Methods A chromatographic column of Diamonsil C18 （150 mmx4.6 mm, 5 μm） was used. The mobile phase was consisted of a mixture of methanol and water （50∶50）. The wave length was 215 nm, the flow rate was 1.0 ml/min, and the column temperature was set to room temperature. Results The percentage amount of phenytoin in three batches of Compound Theophylline and Ephedrine Capsules and Compound Theophylline and Ephedrine Tablets were 97.88% （20121202）, 99.56%（20121203）, 96.41% （20121204） and 102.9%, respectively. Conclusions The method established in this study is simple with accurate and reliable results, and may be useful in quality control for the capsules. |
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| Keywords: | Pharmaceutical preparations Quality control Chromatography,high performance liquid Com-pound theophylline and ephedrine capsules Content |
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