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The role of T-agglutinin in the disappearance of erythrocytes artificially aged by desialylation
Authors:G. Perret  D. Bladier  L. Gattegno  P. Cornillot
Affiliation:U.E.R. expérimentale de Santé, Médecine et Biologie Humaine, 74, rue Marcel Cachin, 93000 Bobigny France
Abstract:The chance discovery of two mouse strains, one with and one without a high presence of serum T-agglutinin, permitted the investigation of the role of this antibody in the disappearance of desialylated erythrocytes, which may be regarded as a model for ageing. The proportional relationship between the quantity of sialic acid removed and the diminution of half-life is not affected by the presence or absence of T-agglutinin. Opsonization by T-agglutinin would therefore appear to be an improbable mechanism. Other possible theories are discussed.
Keywords:Reprint requests should be addressed to G. Perret   Service de Biochimie   U.E.R. expérimentale de Santé   Médecine et Biologie Humaine   74 rue Marcel Cachin   93000 Bobigny   France.
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