| 高质量头孢地尼晶体的制备方法 |
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| 引用本文： | 付德才,石少龙,谷明明,郑美玲,刘倩.高质量头孢地尼晶体的制备方法[J].中国药物化学杂志,2014(4):311-313. |
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| 作者姓名： | 付德才 石少龙 谷明明 郑美玲 刘倩 |
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| 作者单位： | 河北科技大学化学与制药工程学院,河北石家庄050018 |
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| 摘 要： | 目的探索制备高质量头孢地尼的方法,确定制备方法的较佳工艺条件。方法 7-氨基-3-乙烯基头孢烯酸(7-AVCA)与2-(2-氨基-4-噻唑)-2(Z)-三苯甲氧亚氨乙酸活性硫酯(2)缩合后,经甲磺酸中和形成三元复合物而分离,再经磷酸水解脱除保护基析出头孢地尼和磷酸复合物,最后通过精制得到目标化合物头孢地尼。结果与结论该制备方法操作简单,产品质量好,总收率达74.5%。
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| 关 键 词： | 头孢地尼 7-氨基-3-乙烯基头孢烯酸 三苯甲基活性硫酯 制备 |
The preparation of high quality cefdinir crystal |
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| FU De-cai,SHI Shao-long,GU Ming-ming,ZHENG Mei-ling,LIU Qian.The preparation of high quality cefdinir crystal[J].Chinese Journal of Medicinal Chemistry,2014(4):311-313. |
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| Authors: | FU De-cai SHI Shao-long GU Ming-ming ZHENG Mei-ling LIU Qian |
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| Institution: | (Hebei University of Science and Technology, College of Chemical and Pharmaceutical Engineering, Shijiazhuang 050018, China) |
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| Abstract: | High quality cefdinir crystal was obtained by condensation, hydrolysis and purification as well as optimum reaction conditions were determined. The three element complex was seperated from reaction mix- ture after the condensation of 2-benzothiazolyl-（Z）-2-（2-aminothiazol-4-yl ）-2-tripheny-lmethoxyiminothio- acetate with 7-amino-3-vinyl-3-cephem-4-carboxylic acid （7-AVCA） by adding methylsulfonic acid. Using 85 % phosphoric acid in the presence of acetonitrile to deblock triphenylmethyl group gave the solid salt of cefdinir and phosphoric acid. Cefdinir crystal was obtained by purification of cefdinir and phosphoric acid salt with sodium hydrate solution and then acidation in the total yield 74.5 %. The preparation route had the advertage of high quality product and easy operation. |
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| Keywords: | cefdinir 7-AVCA triphenylmethyl activated thioester preparetion |
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