| 除毒河豚肝油对于抗淋巴细胞血清所致小鼠模型的免疫增强作用 |
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| 引用本文： | 舒荣华,蔡仙德,谭剑萍,卫寄英,蒋韵,尹琰,吴芬芬.除毒河豚肝油对于抗淋巴细胞血清所致小鼠模型的免疫增强作用[J].东南大学学报(医学版),1985(2). |
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| 作者姓名： | 舒荣华 蔡仙德 谭剑萍 卫寄英 蒋韵 尹琰 吴芬芬 |
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| 作者单位： | 南京铁道医学院微生物学教研室，南京铁道医学院微生物学教研室，南京铁道医学院微生物学教研室，南京铁道医学院药理教研室，南京铁道医学院药理教研室，南京铁道医学院药理教研室，南京铁道医学院药理教研室 |
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| 摘 要： | 小鼠经注射自制抗T细胞血清后次日的T细胞数和百分率显著下降(P<0.001),以此建立T细胞减少动物模型。小鼠连续使用除毒河豚肝油(0.05ml/鼠/天,S.C.共5天)能使T细胞百分率与药前比下降不明显(P>0.05),而对照组显著(P<0.001);用药8天停药4天的血清血凝素抗体滴度和脾细胞溶血空斑数较对比组高(P<0.001,P<0.02)。表明该药对此模型具有一定免疫增强作用。
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| 关 键 词： | 除毒河豚肝油 抗小鼠 T 淋巴细胞血清 免疫增强作用 |
EFFECT OF FUGU LIVER OIL WITHOUT TTX ON THE IMMUNOLOGIC RESPONSE OF MICE IMMUNOSUPPRESSED BY ANTI-LYMPHOCYTE SERUM |
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| Shu Ronghua Cai Xiande Tan Jianping.EFFECT OF FUGU LIVER OIL WITHOUT TTX ON THE IMMUNOLOGIC RESPONSE OF MICE IMMUNOSUPPRESSED BY ANTI-LYMPHOCYTE SERUM[J].Journal of Southeast Univ: Medical Sci Ed,1985(2). |
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| Authors: | Shu Ronghua Cai Xiande Tan Jianping |
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| Institution: | Shu Ronghua Cai Xiande Tan Jianping Department of Microbiology,NRMC,Nanjing
Wei Jiying Jiang Yun Yin Yan Wu Fengfeng Department of Pharmacology,NRMC,Nanjing |
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| Abstract: | The percentage and number of T-lymphocyte in mice were significantly decreased(p<0.001) the day after anti-lymphocyte serum (0.2ml/mouse i.p.) was injected.The percentage of T-lymphocyte in mice decreased less remarkably (P>0.05)after administration of Fugu Liver Oil without TTX (0.05ml/mouse s.c., once daily for 5 days) than that before the experiment, whereas it decreased significantly(p<0.001)in control group.The hemagglutinin titer and plaque forming cell increased on the 5 th day after the last injection which lasted for 8 days.The results suggest that Fugu Liver Oil without TTX has immunopotentiation in mice pretreated with antilymphocyte serum. |
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| Keywords: | fugu liver oil without TTX anti-lymphocyte serum(ALS) immunopotentiation |
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