体重指数对老年心衰患者N末端脑钠肽浓度的影响

目的：探讨老年慢性心衰（CHF）患者N-末端脑钠肽（NT-proBNP）与体重指数（BMI）之间的关系及临床意义.方法：119例CHF患者按美国心脏病协会（NYHA）分级方法分为心功能Ⅱ级组（n=38）、Ⅲ级组（n=42）及心功能Ⅳ级组（n=38）.以不同BMI值把每组再分为三亚组：体型正常（BMI〈24 kg/m^2）、超重（24 kg/m^2≤BMI＜28kg/m^2）及肥胖亚1组（BMI≥28kg/m^2）.ELISA法测定血浆Nt-proBNP浓度.比较不同心功能组Nt-proBNP浓度差异及同一组不同亚组间Nt-proBNP浓度差异,并在组内进行NT-proBNP与BMI相关性分析.结果：NT-proBNP随心功能分级程度升高而显著增加（P〈0.01）.在同一心功能组中,正常、超重及肥胖亚组血浆NT-proBNP浓度逐渐下降,BMI与NT-proBNP之间存在负相关关系（ P〈0.001）.结论： 老年慢性心衰患者中血浆NT-proBNP浓度随BMI增加而降低.在应用NT-proBNP进行心功能评估时应考虑肥胖因素对其产生的影响.

Body weight index fades the patient N terminal brain sodium peptide density to the old age heart to affect

Objective： Discusses the old age chronic heart to fade （CHF） patient N- terminal brain sodium peptide （NT--proBNP） and between the body weight index （BMI） relations and the clinical significance. Methods： 119 example CHF patient divides into the heart function according to the American Heart disease Association （NYHA） graduation method Ⅱ Level group （n= 38）, Ⅲ Level group （n= 42） and heart funetion Ⅳ Level group （n= 38）. Divides into again by the different BMI value each group three subnits：Build normal （BMI（24 kg/m^2） ,overload （24 kg/m^2≤BMI （28 kg/m^2） and obese Asian 1 group （BMI≥28 kg/m^2）. ELISA law determination blood plasma Nt-proBNP density. Compared with not the concentric function group Nt--proBNP density difference and the identical group during different subnit the Nt--proBNP density difference,and carries on NT--proBNP and the BMI relevance analysis in the group. But finally the NT--proBNP as one desires function graduation degree ascension obviously increases （P〈0. 01 ）. In with wholeheartedly the function group in,normal,overwelght and the obese subnit blood plasma NT--proBNP density drops gradually,between BMI and NT--proBNP has the inverse correlation relations （P〈0. 001） Conclusion： The old age chronic heart fades in the patient the blood plasma NT--proBNP density to increase along with BMI reduces. When carries on the heart function appraisal using NT--proBNP should consider the obese factor the influence which produces to it.