紫绀型与非紫绀型先天性心脏病患儿吸人麻醉药血／气分配系数

目的测定并比较紫绀型与非紫绀型先天性心脏病患儿吸入麻醉药血／气分配系数(B／G)，判断红细胞压积(Hct)对B／G的影响。方法紫绀型与非紫绀型先天性心脏病患儿各10例，平均年龄5岁，采桡动脉血10ml，用两次平衡法测定地氟醚、异氟醚和氟烷的B／G，并测定血浆总胆固醇、甘油三脂、白蛋白、球蛋白浓度和Hct，t检验比较两组间血液成分和吸入麻醉药B／G有无差别。结果紫绀型与非紫绀型先天性心脏病患儿Hct有显著差异(紫绀型为68．7％±11．1％，非紫绀型37．7％±2．9％，P<0．05)；但两组间其他血浆成分和三种吸入麻醉药的B／G无差异(P>0．05)。结论Hct对B／G无影响，紫绀型与非紫绀型先天性心脏病患儿的B／G无显著性差异。

Blood/Gas Partition Coefficients of Volatile Anesthetics in Children with Congenital Heart Disease

Objective:To determine and compare the blood/gas partition coefficients(B/G) of volatile anesthetics in chil-dren with cyanotic or acyanotic congenital heart disease. Methods: Blood samples were obtained from two groups of fastingchildren aged about 5 years old. B/G of desflurane, isoflurane and halothane in each subject was measured by double equilibra-tion technique. Blood hematocrit and the serum concentrations of cholesterol, triglyceride, albumin, globulin were measured.Results:Hematocrit was significantly different between the two groups (cyanosed 68.7 % + 11.1%, cyanotic 37.7% +2.9 %, P < 0.05), but the concentration of the serum constituents and B/G of the three volatile anesthetics were not differentbetween the two groups( P > 0.05 ). Conclusion: Hct has no effect on B/G. B/G values of volatile anesthetics are the same be-tween children with cyanotic and acyanotic congenital heart diseases.