精神分裂症血清肌酸磷酸激酶活性研究

目的：探讨精神分裂症患者血清肌酸磷酸激酶（CPK）活性与病情的关系。方法：对195例精神分裂症患者于治疗前、治疗4和8周末分别进行CPK检测，同时以简明精神病量表（BPRS）、阴性症状量表（SANS）和阳性症状量表（SAPS）评定其情严重度。选取同期本地区健康体检者69名为对照组。结果：精神分裂症在发病期的CPK活性极显著高于对照组，治疗后显著下降，4周末已降至正常范围；在发病期的CPK值与BPRS总分、思维障碍因子分、激活性因子分和SAPS因子分呈显著正相关，好转后相关性降低，至8周末已无相关性；病例组CPK变化值与BPRS总分减分值、激活性因子的减分值和SAPS总分的减分值呈显著正相关。结论：精神分裂症患者在发病期的CPK活性显著升高，与病情关系密切，与阳性症状相平等，这可能是精神分裂症的神经－免疫、代谢相互作用的结果。

A study on the relationship between serum creatine phosphokinase levels and ill -conditions in schizophrenics

Objective:To understand the relationship between serum creatine phosphokinase (CPK)levels and ill conditions in schizophrenics. Method:195 cases with schizophrenia were examined on the serum CPK levels before and after 4,8 weeks of the treatment. At the same time, they were determined with the brief psychiatric rating scale (BPRS),the scale for assessment of negative symptoms (SANS) and the scale for assessment of positive symptoms (SAPS) to show the ill conditions. 69 healthy persons were examined as normal controls. Results:In onset period of schizophrenia, the serum CPK levels showed very significantly higher than those of the control group and obviously decreased after the treatment. At the end of 4 weeks' treatment, they decreased to the normal range.The serum CPK levels in acute onset period showed significantly positive correlations with the scores of BPRS, thought disorder factor, activity factor and SAPS.The correlation declined in accordance with the ill conditions improvement,and at the end of 8 weeks' treatment, they showed no correlation any more. The variety of CPK levels showed significantly positive correlations with the score reductions of BPRS, activity factor and SAPS. Conclusion:In onset period of schizophrenia, the serum CPK levels increased significantly and were closely correlated with positive symptoms. This may be the result of the interaction among neuroendocrine, immunity and metabolism.