| 江苏省霍乱病例病原学特征及与外环境污染间的关系 |
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| 引用本文： | 庄菱,张雪峰,钱慧敏,朱凤才,汤奋扬. 江苏省霍乱病例病原学特征及与外环境污染间的关系[J]. 现代预防医学, 2011, 38(3): 430-431,434 |
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| 作者姓名： | 庄菱 张雪峰 钱慧敏 朱凤才 汤奋扬 |
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| 作者单位： | 江苏疾病预防控制中心,南京,210009 |
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| 摘 要： | [目的]了解江苏省外环境中霍乱弧菌的污染现状,探讨其与病例发生、疾病流行间的关系。[方法]检测水体、水产品和熟食中霍乱弧菌的携带情况,比较外环境来源株与病例株在血清型、耐药性及毒素基因等方面的差异,应用PFGE分型技术分析不同来源菌株的遗传相关性。[结果]3株外环境来源株均为不带毒力、对抗生素敏感的O1群非流行株,病人来源株为具有ctxA、zot、ace、tcpA毒力基因的O139群。11株O139群被分成7种PFGE带型,与O1群相似性系数为76.14%。[结论]外环境来源株在表型及基因水平上与病例株差异较大,不是病例发生的原因。目前霍乱在江苏省处于低频的高度散发状态,近期大规模暴发和流行的可能性较小。
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| 关 键 词： | 霍乱弧菌 外环境 毒力基因 PFGE |
PATHOGENIC CHARACTERISTIC OF CHOLERAE CASES AND ITS CORRELATION WITH ENVIRONMENTAL VIBIRO CHOLERAE POLLUTION IN JIANGSU PROVINCE |
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| ZHUANG Ling,ZHANG Xue-feng,QIAN Hui-min,et al.. PATHOGENIC CHARACTERISTIC OF CHOLERAE CASES AND ITS CORRELATION WITH ENVIRONMENTAL VIBIRO CHOLERAE POLLUTION IN JIANGSU PROVINCE[J]. Modern Preventive Medicine, 2011, 38(3): 430-431,434 |
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| Authors: | ZHUANG Ling ZHANG Xue-feng QIAN Hui-min et al. |
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| Affiliation: | ZHUANG Ling,ZHANG Xue-feng,QIAN Hui-min,et al. (Jiangsu Center for Disease Prevention and Control,Nanjing 210009,China) |
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| Abstract: | [Objective] To explore the environmental vibrio cholerae pollution situation and its correlation with the occurrence and epidemic of cholera in Jiangsu province. [Methods] Examined vibrio cholerae from water, aquatic products and cooked food. Compared serum type, drug-resistance and virulence genes between strains from environment and patients. Analyzed the genetical correlation among strains from different resources by PFGE. [Results] 3 isolates from environment were non-epidemic strains without virulence ... |
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| Keywords: | Vibrio cholerae Environment Virulence gene PFGE |
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