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Tumor escape and progression of HER-2/neu negative breast cancer under immune pressure
Authors:Maciej Kmieciak  Kyle K Payne  Michael O Idowu  Margaret M Grimes  Laura Graham  Maria-Libera Ascierto  Ena Wang  Xiang-Yang Wang  Harry D Bear  Masoud H Manjili
Institution:(1) Department of Microbiology & Immunology, Virginia Commonwealth University Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA;(2) Department of Pathology, Virginia Commonwealth University Massey Cancer Center, 1200 E. Marshall Street, Richmond, VA 980662, USA;(3) Department of Surgery, Virginia Commonwealth University Massey Cancer Center, 1200 E. Marshall Street, Richmond, VA 980011, USA;(4) Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center and Center for Human Immunology (CHI), National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA;(5) Department of Human and Molecular Genetics, Virginia Commonwealth University Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA
Abstract:

Background  

Emerging data from pre-clinical and clinical studies suggest that HER-2/neu-specific T cell responses could induce HER-2/neu antigen loss in the tumor cells. These data suggest that patients with HER-2/neu negative breast cancer might have had HER-2/neu positive premalignant lesions in the past that progressed to HER-2/neu negative breast cancer under HER-2/neu-specific immune pressure.
Keywords:
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