A human ribonuclease induces apoptosis associated with p21WAF1/CIP1induction and JNK inactivation |
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| Authors: | Jessica Castro Marc Ribó Susanna Navarro Maria Victòria Nogués Maria Vilanova Antoni Benito |
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| Affiliation: | 1.Laboratori d'Enginyeria de Prote?nes, Departament de Biologia, Facultat de Ciències,Universitat de Girona,Girona,Spain;2.Departament de Bioquímica i Biologia Molecular, Facultat de Biociències,Universitat Autònoma de Barcelona,Bellaterra,Spain |
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| Abstract: | Background Ribonucleases are promising agents for use in anticancer therapy. Among the different ribonucleases described to be cytotoxic, a paradigmatic example is onconase which manifests cytotoxic and cytostatic effects, presents synergism with several kinds of anticancer drugs and is currently in phase II/III of its clinical trial as an anticancer drug against different types of cancer. The mechanism of cytotoxicity of PE5, a variant of human pancreatic ribonuclease carrying a nuclear localization signal, has been investigated and compared to that of onconase. |
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