帕瑞昔布钠预防儿童七氟醚全麻苏醒期躁动的临床研究

目的观察帕瑞昔布钠用于预防小儿七氟醚全麻苏醒期躁动的效果及安全性。方法择期下腹部手术患儿90例,随机分为三组。A组(手术开始前给予帕瑞昔布钠0.5 mg/kg)、B组(手术开始前给予曲马多2 mg/kg)和C组(手术开始前给予等容生理盐水)各30例,三组均以8%七氟烷、维库溴铵、舒芬太尼诱导,术中以2%～5%七氟烷维持。分别记录术毕患儿手术时间、停药至清醒时间、拔管时间、躁动评分和疼痛评分。观察患儿各种不良反应(如嗜睡、呼吸抑制、恶心、呕吐等),术后24 h随访。结果患儿苏醒期躁动发生率A组明显低于B组和C组,B组低于C组(p<0.01);拔管后15、30、45、60 min VAS评分A组显著低于B组和C组,B组低于C组(p<0.01)。术后24 h内三组患儿均无心律失常、呼吸抑制、凝血功能异常发生,恶心呕吐、头晕头痛、畏寒发热、心悸、嗜睡、倦怠等不良反应率差异无统计学意义(p>0.05)。结论帕瑞昔布钠预防小儿全麻苏醒期躁动的效果良好,起效快,作用时间长,无明显不良反应,可安全用于小儿七氟醚全麻术后躁动。

PARECOXIB PREVENTS RESTLESSNESS DURING WAKING-UP FROM SEVOFLURANE ANESTHESIA IN CHILDREN

Objective To observe the effect of parecoxib on preventing restlessness during waking up from sevoflurane anesthesia in children.Methods A total of 90 patients undergoing sevoflurane anesthesia were randomly divided into 3 groups with 30 cases each.Group A received perecoxib 0.5 mg/kg iv.before operation,Group B received tramadol 2 mg/kg and Group C received equal volume of normal saline.The occurrence of restlessness was observed during waking-up period in PACU.Results The rates of restlessness was signifi...