复方甲亢片治疗甲状腺功能亢进症合并肝损害的临床研究

目的：探讨复方甲亢片治疗甲亢合并肝损害的临床疗效。方法：对明确诊断的40例甲亢合并肝损害患者随机分别采用复方甲亢片治疗（治疗组）、西药治疗（对照组）观察。结果：治疗组、对照组临床总有效率分别为85．00％、80．00％，经Ridit分析，差异无显著性意义（P〉0．05），两组患者经治疗后FT3。FT4、ALT、AST明显降低，TSH升高，但两组比较差异无显著性意义（P〉0．05）；治疗组在对γ-GT、ALP、TBil指标改善方面有明显优势（P〈0．05）；治疗组症状改善明显，多汗、乏力、口苦、胁痛等症状的改善与对照组比较差异有显著性意义（P〈0．05）。结论：甲亢患者合并肝损害时治疗甲亢是首要的，中药配合小剂量他巴唑（即复方甲亢片）同样能达到大剂量他巴唑配降酶护肝西药的效果，并在改善甲亢合并肝损害症状及综合治疗作用方面有明显优势。

Clinical study on treatment of hyperthyroidism with liver damage by Fufangjiakang tablets

Objective： To study the effects of Fufangjiakang Tablets on hyperthyroidism with liver damage. Methods： For clear diagnosis of 40 eases of hyperthyrodism in patients with liver damage were divided into two groups, one group were used Fufangjiakang tablets （treatment group）, the other group were used western medicine treatment （control group） . Results： In the treatment group and the control group with a total clinical efficiency of 85.00% , 80. 00% , after analysis Ridit no significant difference （P 〉 O. 05） . The treatment group can significantly reduce FT3 , FT4, ALT, AST, and elevated TSH, no significant difference （ P 〉 0.05 ） in the two groups. They, the γ-GT, ALP, TBil indicators, have improved significantly advantage in the treatment group （ P 〈 0. 05） , and they, sweating, weakness, bitter, chest-side ache, and so on, have improved significantly advantage in the treatment group （ P 〈 0. 05 ） . Conclusion： For hyperthyroidism with liver damage, it was primary to treat hyperthroidism. It, with small dose of MMI and Herbs （ Fufangjiakang Tablets）, can get the same effects of the treatment which used large dose MMI, reducing enzyme medicine and protecting liver medicine, and has obvious advantages in improving symptoms and effects of comprehensive treatment of hyperthyroidism with liver damage.