Leukemia in Down Syndrome: A Review |
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| Authors: | Alvin Zipursky Annete Poon John Doyle |
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| Affiliation: | a Division of Hematology/Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada |
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| Abstract: | The incidence of leukemia is higher in children with Down syndrome (DS) than in normals. In approximately 50% of cases the type of leukemia is acute megakaryoblastic leukemia (AMKL) and it occurs during the first 4 years of life. The leukemic cell also has features of erythroid progenitors and therefore appears to be a precursor cell with biphenotypic properties. |
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| Keywords: | leukemia Down syndrome megakaryoblast erythroleukemia |
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