Pulmonary complications of immune reconstitution inflammatory syndromes in HIV-infected patients |
| |
| Authors: | Kristina CROTHERS AND Laurence HUANG |
| |
| Affiliation: | Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut and;Division of Pulmonary and Critical Care Medicine and HIV/AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA |
| |
| Abstract: | Immune reconstitution inflammatory syndrome (IRIS) describes a paradoxical worsening of clinical status related to recovery of the immune system, as can occur after the initiation of highly active antiretroviral therapy (HAART) in HIV-infected patients. Most commonly, IRIS results from opportunistic infections that can unmask or develop paradoxical worsening following HAART. Cancers, autoimmune conditions and sarcoidosis have also been associated with IRIS. Pulmonary complications may be frequently encountered. This article reviews the types and clinical presentation of IRIS, with a focus on the pulmonary manifestations. Management and outcome of IRIS are considered. |
| |
| Keywords: | AIDS antiretroviral therapy highly active HIV immune reconstitution inflammatory syndrome lung disease |
|
|
