溃疡性结肠炎灌肠液治疗溃疡性结肠炎的临床疗效观察

目的：观察中草药灌肠对溃疡性结肠炎的临床疗效。方法：将60例溃疡性结肠炎患者给予自拟灌肠液治疗,检测血清细胞因子水平白介素1β（Interleukin-1β,IL-1β）、肿瘤坏死因子（Tumor Necrosis Factor-α,TNF-α）、一氧化氮合酶-3（内皮型）（Nitric Oxide Synthase-3,Nos-3/eNos）的变化趋势以观察中草药液灌肠对溃疡性结肠炎的临床疗效。结果：治疗1个疗程后,总有效率达93.33%,IL-1β平均提升了19.7%,TNF-α平均降低了14.7%,Nos-3/eNos平均降低了20.8%。结论：溃疡性结肠炎灌肠液在防治溃疡性结肠炎方面,疗效可靠,使用方便,造价低廉,值得临床推广。

Observation on Clinical Curative Effect of Kuijie Enema in Treating Ulcerative Colitis

Objective： To observe the clinical curative effects of Chinese herbal medicine enema in treating ulcerative colitis. Methods： Sixty patients with ulcerative colitis were given the treatment of self-made enema. They were given the detection of serum cytokines,such as IL-1 β,TNF- α and Nos-3 / eNos to observe the clinical curative effects of the Chinese herbal medicine enema on ulcerative colitis. Results： After a course of treatment,the total effective rate was 93. 33%. The level of IL-1β was promoted by 19. 7% on average,and the level of TNF-α was reduced by an average of 14. 7%. The level of Nos-3 / e Nos was decreased by 20. 8%. Conclusion： In the treat- ment of UC,Chinese medicine Kuijie enema shows the advantages of reliable curative effect,easy application,and low cost,which is worth of clinical application.