心肌梗死后大鼠行为学变化的特征分析

目的：研究心肌梗死后大鼠行为学的变化特征,为下一步研究心肌梗死后抑郁发生的机制和临床治疗药物的筛选提供实验动物模型。方法：采用手术法结扎大鼠心脏左冠状动脉前降支制作大鼠心肌梗死模型,采用蔗糖水消耗实验和敞箱实验观察大鼠的行为学变化。结果：大鼠急性心肌梗死后4周,大鼠活动总路程、总时间、直立次数、直立时间以及糖水消耗百分比均明显减少（P〈0.05或P〈0.01）。结论：心肌梗死后大鼠出现活动度下降,对新鲜环境的好奇程度下降以及快感的缺乏。提示心肌梗死后大鼠确实存在着抑郁症状,是进一步研究心梗后抑郁发生机制的理想动物模型。

Analysis of the Behavior Changes of Rats after Myocardial Infarction

Objective： To investigate the behavior changes of rats after myocardial infarction,so as to provide animal models for studying the mechanism of depression after myocardial infarction and the treatment medicine. Methods： The rats were given thoracotomy and left front descending coronary artery ligation while sham ligation control rats received thoracotomy without ligation. Sucrose water consump- tion test and open-field test were evaluated 4 weeks after surgical operation. Results： The score of horizontal movement,vertical move- ment and the consumption of sucrose were significantly decreased（ P 0. 05 or P 0. 01）. Conclusion： After myocardial infarction,the rats decrease activity,lose interests in new environment and lack pleasure,all of which indicate the symptoms of depression. They can be ideal animal models for further study on depression after myocardial infarction.