口腔颌面部肿瘤与唾液表皮生长因子关系的初步研究

目的：探讨唾液表皮生长因子（EGF）含量与口腔颌面部肿瘤之间的关系及其临床意义。方法：以^125I-EGF为配体，用放射免疫法，对123例口腔面部肿瘤及炎症患者唾液EGF（sEGF)含量进行测定分析，同时以40例健康成年人sEGF为对照。结果：腺恶性肿瘤sEGF含量显著性高于良性肿.,一两者均明显高于正常对照组。粘膜鳞癌及复发，癌前病变患者sEGF均较正常对照组明显升高，但各组间无显著性差异，仅呈上升趋势（淋巴结转移患者较正常对照组升高无显著性）。口腔颌面部炎症患者sEGF较对照组升高有高度显著性。论：sEGF含量在涎腺肿瘤及粘膜鳞癌，炎症中均有不同程度的升高。

A Study on theRelationship between the Changes of Salivary EGF and Oromaxillofacial Tumors

Objective To investigate the relationship between the changes of salivary epidermal growth factor(sEGF) concentration and oromaxillofacial tumors so as to find out its potential clinical value. Methods The saliva of 123 patients with oromaxillofacial tumors,inflammations and precancerous lesions were measured for EGF concentration by radioimmunoassay(RIA) with the ligand 125 I EGF and the saliva of 40 normal adults as the control. Results Compared with the control,sEGF level of malignant,benign salivary gland tumors increased obviously;the former is higher than the latter significantly. The sEGF levels of patients with squamous cell carcinoma(SCC) of mucosa,recurrence and precancerous lesion were significantly higher than that of the control. There was no significant difference among the groups,but there was a tendency to increase by degrees. Compared with the control,the increase of the sEGF level of SCC patients with lymph node metastasis was of no significance. The sEGF level of oromaxillofacial inflammation was significantly higher than that of control. Conclusion The sEGF levels in patients with salivary gland tumor,SCC,inflammation increased in different degrees. [