Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide |
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Authors: | Kiyoshi Takegawa Kunitoshi Mitsumori Hiroshi Onodera Kazuo Yasuhara Keisuke Kitaura Takeo Shimo Michihito Takahashi |
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Institution: | Division of Pathology, National Institute of Health Sciences, 1-18-1 Kami-yoga, Setagaya-ku, Tokyo 158 |
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Abstract: | In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high-dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non-genotoxic, proliferation-dependent mechanism. |
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Keywords: | Squamous cell carcinoma Salivary gland Potassium iodide Rat |
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