| Bcl-2在肺癌中的表达及意义 |
| |
| 引用本文： | 闫海军,陈明伟. Bcl-2在肺癌中的表达及意义[J]. 临床肺科杂志, 2013, 18(1): 14-15 |
| |
| 作者姓名： | 闫海军 陈明伟 |
| |
| 作者单位： | 南京医科大学附属南京第一医院呼吸内科;西安交通大学医学院第一附属医院呼吸内科 |
| |
| 摘 要： | 目的探讨Bcl-2蛋白在肺癌中的表达与肺癌临床病理因素的关系。方法采用免疫组织化学方法，检测肺癌组织中Bcl-2蛋白表达的情况。结果在49例肺癌组织中，Bcl-2蛋白的阳性表达率是34．7％，显著高于对照组（12．50%）（P〈0．05），在非小细胞肺癌组中随着病理分化程度不同，Bcl-2蛋白阳性表达呈显著性差异（P〈0．01）；在小细胞肺癌和非小细胞肺癌组Bcl-2蛋白表达也具有统计学差异（P〈0．01）。结论Bcl-2基因蛋白阳性表达率在小细胞肺癌组中显著高于非小细胞肺癌组，并可作为早期诊断肺癌的标志物。
|
| 关 键 词： | 免疫组织化学 肺癌 Bcl-2基因 组织分化程度 |
Expression of Bcl-2 and its clinical significance in patients with lung cancer |
| |
| YAN Hai-jun,CHEN Ming-wei. Expression of Bcl-2 and its clinical significance in patients with lung cancer[J]. Journal of Clinical Pulmonary Medicine, 2013, 18(1): 14-15 |
| |
| Authors: | YAN Hai-jun CHEN Ming-wei |
| |
| Affiliation: | 1.Department of Respiratory Medicine,Nanjing First Affiliated Hospital,Nanjing Medical University,Nanjing 210006,China;2.Department of Respiratory of Medicine,the First Affiliated Hospital of Xi′an Jiao tong University,Xi′an,Shanxi 710061,China |
| |
| Abstract: | Objective To explore the relationship between the expression of Bcl-2 and pathological factors in patients with lung cancer. Methods The expression of Bel-2 was detected by immunohistochemical ultrasensitive TM S-P method. Results The positive expression rate of Bcl-2 was 34. 7% in 49 lung cancer tissues, which was obviously higher than 12.5% in the controls （P 〈0.01 ）. With the different degrees of differentiation in the non-small cell lung cancer group, the positive expression of Bcl-2 showed statistical difference, and so did in the small cell lung cancer group （ P 〈 0. 01 ）. Conclusion The expression level of Bcl-2 was obviously higher in SCLC than in NSCLC （P 〈0. 01 ）, and it can be regarded as an important index in the early diagnosis of lung cancer. |
| |
| Keywords: | immunohistochemistry lung cancer Bcl-2 gene differentiation degree |
| 本文献已被 CNKI 维普 等数据库收录！ |
