非小细胞肺癌病灶大小及密度与PET/CT标准摄取值相关性研究

目的]探讨非小细胞肺癌(NSCLC)PET/CT显像中病灶径长(最大径、最小径)、密度与标准摄取值(SUV)之间的相关性;并比较将影响因素扣除后,不同组织学类型、不同分期肺癌标准摄取值(SUV)间的差异。方法]研究对象为2010年6月—2011年4月行PET/CT检查疑诊肺癌,后经病理或细胞学确诊为原发性鳞癌无转移患者9例,鳞癌有转移患者13例(和/或淋巴结及远处病灶转移),腺癌无转移患者13例,腺癌有转移患者16例(淋巴结和/或远处转移)。对病灶径长及病灶密度与SUVmax分别进行单因素及多因素相关分析。对肺癌各组织学类型及不同分期间SUV进行协方差分析。结果]最大径、最小径及密度与SUVmax之间的单因素相关分析P值均<0.001,R分别为0.600、0.666、0.452,即均呈明显正相关关系。三个变量与SUV进行多因素回归分析,P值<0.05;R为0.692,得到回归方程Y=1.353+0.537×最大径+3.036×最小径+0.024×密度。四组间协方差分析结果为:P值>0.05。结论]病灶最大径、最小径及病灶密度均与SUV呈明显正相关关系,将各影响因素扣除后,不同组织学类型及不同分期非小细胞肺癌SUVmax间没有明显差异。

Covariance analysis between SUVmax of NSCLC and influencing clinical factors

Objective]To investigate if the tumor size and CT value influence fluorodeoxyglucose(FDG) uptake,and the relationship between SUV and different clinical stage of adenocarcinoma(AC) and squamous cell carcinoma(SCC) in the lungs.Methods]We reviewed the data of 9 cases of squamous carcinoma without metastases,13 cases with metastases,13 cases of adenocarcinoma without metastases and 16 cases with metastases,who underwent FDG PET/CT in the nuclear medicine department of our hospital between June 2010 and May 2011.The correlation between SUVmax and some influencing clinical factors was analyzed,and evaluated the differences SUVmax between AC and SCC through covariance analysis.Results]Either tumor size(maximum and minimum diameter) or CT value showed significantly correlated with SUVmax(P<0.05).Covariance analysis demonstrated that there was no significant difference between AC and SCC(P>0.05).Conclusion]SUVmax is significant associated with the tumor size(maximum and minimum diameter) and the CT value,but there is no significant difference of the SUVmax between AC and SCC.