氯丙嗪宝刀不老——与氯氮平疗效的对照观察

目的；了解氯丙嗪与氯氮平治疗以阳性症状为主的精神分裂症的临床疗效与副反应。方法：选择符合ＣＣＤＭ－２－Ｒ诊断标准，同时符合Ａｎｄｒｅａｓｅｎ阳性神经分裂症标准的２００例病人，随机均分为单用氯丙嗪或氯氮平治疗两组，以简明精神病量表（ＢＰＲＳ）评定疗效，以不良反应症状量表（ＴＥＳＳ）观察副反应。

Comparison between chlorpromazine and clozapine in the treatment of positive symptoms in schizophrenia

Objective: To compare the therapeutic and side effects of chlorpromazine (CPZ) and clozapine in the treatment of schizophrenia. Method: 200 patients with diagnosis of schizophrenia according to CCMD2R and positive symptoms according to SAPS by Andreason were randomly assigned to treatment with either CPZ or clozapine for eight weeks. Clinical improvement and side effects were monitored with the BPRS and TESS. Results: The mean response time was significantly shorter for the CPZ than clozapine group (P<0001). Factor 3 and 4 of BPRS at second and fourth decreased significantly more compared with pretreatment rating in the CPZ than clozapine group(P<01). The side effects between two groups were also different. Conclusion: These results suggest that chlorpromazine excels clozapine in the treatment of positive symptoms of schizophrenia.