| 肿瘤多药耐药与自噬的研究进展 |
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| 引用本文： | 赵英迪,刘克辛. 肿瘤多药耐药与自噬的研究进展[J]. 现代药物与临床, 2018, 41(1): 5-13 |
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| 作者姓名： | 赵英迪 刘克辛 |
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| 作者单位： | 大连医科大学药学院, 辽宁 大连 116044,大连医科大学药学院, 辽宁 大连 116044 |
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| 基金项目： | 国家自然科学基金项目（81473280） |
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| 摘 要： | 肿瘤多药耐药（multidrug resistance，MDR）对肿瘤的药物治疗的疗效有严重的影响。多药耐药拥有十分复杂的发生发展的机制。通过讨论自噬与药物抗肿瘤时的相互影响，旨在阐明自噬与肿瘤细胞多药耐药的关系，为今后抗肿瘤药物治疗的临床应用提供新的思路。
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| 关 键 词： | 肿瘤 自噬 多药耐药 |
| 收稿时间： | 2017-06-05 |
Advances in multidrug resistance and autophagy of antitumor drugs |
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| ZHAO Yingdi and LIU Kexin. Advances in multidrug resistance and autophagy of antitumor drugs[J]. Drugs & Clinic, 2018, 41(1): 5-13 |
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| Authors: | ZHAO Yingdi and LIU Kexin |
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| Affiliation: | College of Pharmacy, Dalian Medical University, Dalian, Liaoning 116044, China and College of Pharmacy, Dalian Medical University, Dalian, Liaoning 116044, China |
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| Abstract: | Tumor multidrug resistance (MDR) has seriously affected the efficacy of drug therapy on tumors. The occurrence of multidrug resistance has a very complex mechanism. In this paper, we discuss the relationship between autophagy and drug anti-tumor, aiming to elucidate the relationship between autophagy and multidrug resistance in tumor cells, and provide new ideas for the clinical application of anticancer drugs. |
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| Keywords: | tumor autophagy multidrug resistance |
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