Teratogenicity of three polychlorinated dibenzofurans in C57BL/6N mice |
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| Authors: | L S Birnbaum M W Harris E R Barnhart R E Morrissey |
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| Affiliation: | 1. Systemic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 USA;2. Toxicology Branch, Center for Disease Control, Atlanta, Georgia 30333 USA;1. Department of Radiology and Medical Imaging, Division of Vascular and Interventional Radiology, University of Virginia, 1215 Lee St., Charlottesville, VA 22908;2. Department of Public Health Sciences, University of Virginia, 1215 Lee St., Charlottesville, VA 22908;3. Interventional Radiology Department, Saint Louis Hospital, Lisbon, Portugal;1. Department of Plant and Soil Science, Texas Tech University, Lubbock, TX 79409, USA;2. Carrington Research Extension Center, North Dakota State University, Carrington, ND, USA;3. School of Geography & Environmental Studies, University of the Witwatersrand, WITS 2050 Johannesburg, South Africa;4. Department of Land, Water and Environment, Faculty of Agriculture, The University of Jordan, Amman 11942, Jordan;5. Department of Plant Sciences and Plant Pathology, Montana State University, 119 Plant Bioscience Building, Bozeman, MT 59717-3150, USA;6. Northeast Region, Louisiana State University Agricultural Center, 212-B Macon Ridge Road, Winnsboro LA 71295, USA;7. Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China;1. Department of Pediatrics/Neonatology, Children''s Hospital of Montefiore/Einstein, Bronx, NY, USA;2. Department of Pediatrics/Nephrology, Children''s Hospital of Montefiore/Einstein, Bronx, NY, USA;1. Interventional Radiology and Endovascular Surgery Department, University of Sao Paulo Medical School, Dr. Enéas de Carvalho Aguiar Avenue, 255, Cerqueira César, 05403000 São Paulo, Brazil;2. Radiology Institute, and Urology Department, University of Sao Paulo Medical School, Dr. Enéas de Carvalho Aguiar Avenue, 255, Cerqueira César, 05403000 São Paulo, Brazil;3. The Dartmouth Center for Health Care Delivery Science, Hanover, New Hampshire;1. College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyamaku, Nagoya, Aichi 463-8521, Japan;2. Faculty of Nutrition, Kobe Gakuin University, 518 Arise, Ikawadani-cho, Nishi-ku, Kobe, Hyogo 651-2180, Japan |
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| Abstract: | Polychlorinated dibenzofurans (PCDFs) are widespread environmental contaminants which have been detected in human tissues and implicated in several poisoning incidents. Their toxic effects are similar to those observed with other related halogenated aromatic hydrocarbons such as TCDD. The teratogenic effects of three PCDFs, 1,2,3,7,8-pentachlorodibenzofuran (1-PeCDF), 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF), and 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF), were assessed in C57BL/6N mice. Pregnant mice were exposed on Gestation Days 10-13 to 10 ml corn oil/kg containing PCDFs. The dams were killed on Gestation Day 18 and maternal and fetal toxicity were assessed. All three compounds were highly teratogenic, with very steep and parallel dose-response curves for the two diagnostic indicators of dioxin-like teratogenicity, hydronephrosis, and cleft palate. 4-PeCDF was the most teratogenic with an ED50 of 36 micrograms/kg for cleft palate and 7 micrograms/kg for hydronephrosis. 4-PeCDF was approximately 4 times as potent as 1-PeCDF and 10 times as potent as HCDF. The teratogenic responses occurred at a dose below that where any obvious maternal or fetal toxicity was detected. Thus, these three compounds cause teratogenic responses similar to those seen with TCDD but are only 1/10 to 1/100 as potent. |
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