血管重建在食管静脉曲张破裂出血中的发病机制

食管静脉的异常血流动力学变化是造成食管静脉曲张破裂的主要因素,高流量及流速促进静脉血管壁的结构变化,包括内皮功能受损、平滑肌功能障碍及细胞外间质重分布,即为静脉血管重建,强度及顺应性的下降降低了血管壁所能承受的流体张力,间接地参与了曲张静脉破裂出血的发生发展机制。

Vascular remodeling in the pathogenesis of varice bleeding

The abnormal hemodynamics of esophageal vein in patiens with cirrhosis is the main cause of varice dleeding. Some patnological changes which call vascular remodeling have occurred in the wall of the vein,including endothelium injury, vascular smooth muscle cell dysfunction and extracellular matrix remodeling.The construction of vascular wall changes and the intensity and compliance decrease.When the mechanical strain of the blood flow in creases,the varice bleeding may be occur.