| 内皮抑素抑制肿瘤生长和转移的机制 |
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| 引用本文： | 王永春,朱运奎. 内皮抑素抑制肿瘤生长和转移的机制[J]. 国际呼吸杂志, 2009, 29(2). DOI: 10.3760/cma.j.issn.1673-436X.2009.02.009 |
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| 作者姓名： | 王永春 朱运奎 |
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| 作者单位： | 兰州军区兰州总医院呼吸内科,730050;兰州军区兰州总医院呼吸内科,730050 |
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| 摘 要： | 恶性肿瘤的生长和转移离不开新生血管.抗肿瘤血管生成是近年来出现的倍受关注的一种种肿瘤治疗新方法,并得到了较为广泛和深入的研究.内皮抑素是胶原蛋白ⅩⅧ的C末端水解片段,是重要的内源性血管抑制因子,在抗肿瘤血管生成方面表现出显著效果,其为治疗恶性肿瘤提供了新的途径.本文就内皮抑素的生物学特性及其在抑制肿瘤生长和转移作用机制中的研究进展作一介绍.
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| 关 键 词： | 内皮抑素 血管生成 肿瘤生长和转移 |
Inhibition of growth and metastasis of tumor by angiogenesis inhibitor endostatin |
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| WANG Yong-chun,ZHU Yun-kui. Inhibition of growth and metastasis of tumor by angiogenesis inhibitor endostatin[J]. International Journal of Respiration, 2009, 29(2). DOI: 10.3760/cma.j.issn.1673-436X.2009.02.009 |
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| Authors: | WANG Yong-chun ZHU Yun-kui |
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| Abstract: | The growth and metastasis of malignant tumors depend on angiogenesis. Antiangiogenesis of tumor is a new therapy in recent years, and is extensively and deeply researched. Endostatin, the C-term inalproteolytic fragment of collagen Ⅹ Ⅷ ,is a potent endogenous angiogenesis inhibitor, has significant effect on antiangiogenesis of tumor, and provides a new way for the treatment of malignant tumor. The article summarizes the research advancement of inhibiting tumor growth and metastasis regarding endostatin. |
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| Keywords: | Endostatin Angiogenesis Tumor growth and metastasize |
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